Norplant and Vaginal bleeding - a phase IV clinical study of FDA data

Summary:

Vaginal bleeding is reported as a side effect among people who take Norplant (levonorgestrel), especially for people who are 20-29 old, have been taking the drug for 2 - 5 years also take Tylenol,.

The phase IV clinical study analyzes which people have Vaginal bleeding when taking Norplant. It is created by eHealthMe based on reports of 6,416 people who have side effects when taking Norplant from the FDA, and is updated regularly.

What is Norplant?

Norplant has active ingredients of levonorgestrel. It is often used in birth control. eHealthMe is studying from 6,430 Norplant users. Check the latest studies of Norplant.

What is Vaginal bleeding?

Vaginal bleeding is found to be associated with 1,128 drugs and 1,539 conditions by eHealthMe. Check the latest studies of Vaginal bleeding.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 28, 2026

6,416 people reported to have side effects when taking Norplant.
Among them, 81 people (1.26%) have Vaginal bleeding.

Among these 81 people:

How long have people been on Norplant when they have Vaginal bleeding? *

What is the age of people who have Vaginal bleeding when taking Norplant? *

What are other drugs people take besides Norplant? *

What are other side effects people have besides Vaginal bleeding? *

Weight Increased: 20 people, 24.69%
Menstruation Irregular: 17 people, 20.99%
Unintended Pregnancy (unwanted pregnancies as well as those that are mistimed): 16 people, 19.75%
Heavy Or Prolong Menstrual Bleeding: 14 people, 17.28%
Ovarian Cysts (fluid filled sacs of the ovary): 12 people, 14.81%
Fatigue (feeling of tiredness): 11 people, 13.58%
Ectopic Pregnancy (a pregnancy in which the foetus develops outside the uterus, typically in a fallopian tube): 11 people, 13.58%
Complication Of Drug Device Removal: 10 people, 12.35%
Menometrorrhagia (a condition in which prolonged or excessive uterine bleeding occurs irregularly and more frequently than normal): 10 people, 12.35%
Hypoaesthesia (reduced sense of touch or sensation): 9 people, 11.11%

* Approximation only. Some reports may have incomplete information.

Do you take Norplant and have Vaginal bleeding?

- Check whether Vaginal bleeding is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Norplant:

Norplant (6,430 reports)

Vaginal bleeding treatments and more:

Vaginal bleeding (49,485 reports)

Browse all side effects of Norplant:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Vaginal bleeding:

Vaginal bleeding (1,128 drugs)

Browse all the conditions that are associated with Vaginal bleeding:

Vaginal bleeding (1,539 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on levonorgestrel (the active ingredients of Norplant) and Norplant (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.