Nortriptyline hydrochloride and Death - a phase IV clinical study of FDA data

Summary:

Death is reported as a side effect among people who take Nortriptyline hydrochloride (nortriptyline hydrochloride), especially for people who are female, 60+ old, have been taking the drug for < 1 month also take Gabapentin, and have Primary pulmonary hypertension.

The study is created by eHealthMe based on reports of 3,475 people who have side effects when taking Nortriptyline hydrochloride from the FDA, and is updated regularly.

What is Nortriptyline hydrochloride?

Nortriptyline hydrochloride has active ingredients of nortriptyline hydrochloride. It is often used in migraine. eHealthMe is studying from 4,817 Nortriptyline hydrochloride users. Check the latest studies of Nortriptyline hydrochloride.

On Jul, 06, 2026

3,475 people reported to have side effects when taking Nortriptyline hydrochloride.
Among them, 44 people (1.27%) died.

Could Nortriptyline hydrochloride cause Death?

Among these 44 people:

How long have people been on Nortriptyline hydrochloride when they died? *

What is the gender of people who died when taking Nortriptyline hydrochloride? *

female: 69.7 %
male: 30.3 %

What is the age of people who died when taking Nortriptyline hydrochloride? *

What are other drugs people take besides Nortriptyline hydrochloride? *

What are other side effects people have before they died? *

Drug Ineffective: 5 people, 11.36%
Delirium (wild excitement): 4 people, 9.09%
Sedation: 4 people, 9.09%
Nausea (feeling of having an urge to vomit): 3 people, 6.82%
Breathing - Slowed Or Stopped: 2 people, 4.55%
Dyspnea (difficult or laboured breathing): 2 people, 4.55%
Osteomyelitis (infection of bone): 2 people, 4.55%
Neuropathy Peripheral (surface nerve damage): 2 people, 4.55%
Pain In Extremity: 2 people, 4.55%
Cardiac Arrest: 2 people, 4.55%

What are the existing conditions these people have? *

Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 4 people, 9.09%
Primary Pulmonary Hypertension (primary high blood pressure that affects the arteries in the lungs and the right side of your heart): 4 people, 9.09%
Eczema (patches of skin become rough and inflamed, with itching and bleeding blisters): 3 people, 6.82%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 3 people, 6.82%
Polyneuropathy (neurological disorder that occurs when many peripheral nerves throughout the body malfunction simultaneously): 2 people, 4.55%
Urticaria (rash of round, red welts on the skin that itch intensely): 1 person, 2.27%
Ankylosing Spondylitis (type of arthritis affecting the spine): 1 person, 2.27%
Asthma: 1 person, 2.27%
Burkitt Lymphoma (cancer of the lymphatic system): 1 person, 2.27%
Chronic Myeloid Leukaemia (long lasting type of cancer that starts in the blood-forming cells of the bone marrow and invades the blood): 1 person, 2.27%

* Approximation only. Some reports may have incomplete information.

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Nortriptyline hydrochloride:

Nortriptyline hydrochloride (4,817 reports)

Expand to all the drugs that have ingredients of nortriptyline hydrochloride:

Death and drugs with ingredients of nortriptyline hydrochloride (641 reports)

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Nortriptyline hydrochloride:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Death:

Death (3,141 drugs)

Browse all the conditions that are associated with Death:

Death (3,686 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on nortriptyline hydrochloride (the active ingredients of Nortriptyline hydrochloride) and Nortriptyline hydrochloride (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

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