Nph insulin and Joint swelling - a phase IV clinical study of FDA data

Summary:

Joint swelling is reported as a side effect among people who take Nph insulin (insulin susp isophane beef), especially for people who are female, 40-49 old, also take Metformin, and have High blood pressure.

The phase IV clinical study analyzes which people have Joint swelling when taking Nph insulin. It is created by eHealthMe based on reports of 1,834 people who have side effects when taking Nph insulin from the FDA, and is updated regularly.

What is Nph insulin?

Nph insulin has active ingredients of insulin susp isophane beef. It is often used in diabetes. eHealthMe is studying from 1,871 Nph insulin users. Check the latest studies of Nph insulin.

What is Joint swelling?

Joint swelling is found to be associated with 2,120 drugs and 2,938 conditions by eHealthMe. Check the latest studies of Joint swelling.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 31, 2026

1,834 people reported to have side effects when taking Nph insulin.
Among them, 21 people (1.15%) have Joint swelling.

Among these 21 people:

What is the gender of people who have Joint swelling when taking Nph insulin? *

female: 66.67 %
male: 33.33 %

What is the age of people who have Joint swelling when taking Nph insulin? *

What are other drugs people take besides Nph insulin? *

What are other side effects people have besides Joint swelling? *

Joint Pain: 17 people, 80.95%
Pain: 15 people, 71.43%
Peripheral Swelling: 12 people, 57.14%
Pain In Extremity: 11 people, 52.38%
Rashes (redness): 9 people, 42.86%
Gait Disturbance: 9 people, 42.86%
Dizziness: 9 people, 42.86%
Fever: 8 people, 38.10%
Fatigue (feeling of tiredness): 8 people, 38.10%
Malaise (a feeling of general discomfort or uneasiness): 8 people, 38.10%

What are the existing conditions these people have? *

High Blood Pressure: 16 people, 76.19%
High Blood Cholesterol: 13 people, 61.90%
Psoriatic Arthropathy (inflammation of the skin and joints with kin condition which typically causes patches (plaques) of red, scaly skin to develop): 7 people, 33.33%
Thyroid Diseases: 6 people, 28.57%
Psoriasis (immune-mediated disease that affects the skin): 4 people, 19.05%
Depression: 4 people, 19.05%
Type 2 Diabetes: 4 people, 19.05%
Acromegaly (body produces too much growth hormone, leading to excess growth of body tissues): 4 people, 19.05%
Pituitary Tumor: 3 people, 14.29%
Blood Glucose Abnormal: 3 people, 14.29%

* Approximation only. Some reports may have incomplete information.

Do you take Nph insulin and have Joint swelling?

- Check whether Joint swelling is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
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Related studies:

Effectiveness of, long term effects of, and alternative drugs to Nph insulin:

Nph insulin (1,871 reports)

Joint swelling treatments and more:

Joint swelling (143,797 reports)

Browse all side effects of Nph insulin:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Joint swelling:

Joint swelling (2,120 drugs)

Browse all the conditions that are associated with Joint swelling:

Joint swelling (2,938 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on insulin susp isophane beef (the active ingredients of Nph insulin) and Nph insulin (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.