Nubain and Cardiac failure aggravated - a phase IV clinical study of FDA data

Summary:

Cardiac failure aggravated is reported as a side effect among people who take Nubain (nalbuphine hydrochloride), especially for people who are female, 20-29 old, also take Protonix, and have Depression.

The phase IV clinical study analyzes which people have Cardiac failure aggravated when taking Nubain. It is created by eHealthMe based on reports of 1,718 people who have side effects when taking Nubain from the FDA, and is updated regularly.

What is Nubain?

Nubain has active ingredients of nalbuphine hydrochloride. It is often used in pain. eHealthMe is studying from 1,749 Nubain users. Check the latest studies of Nubain.

What is Cardiac failure aggravated?

Cardiac failure aggravated is found to be associated with 1,826 drugs and 760 conditions by eHealthMe. Check the latest studies of Cardiac failure aggravated.

On Jul, 29, 2026

1,718 people reported to have side effects when taking Nubain.
Among them, 12 people (0.7%) have Cardiac failure aggravated.

Could Nubain cause Cardiac failure aggravated?

Among these 12 people:

What is the gender of people who have Cardiac failure aggravated when taking Nubain? *

female: 91.67 %
male: 8.33 %

What is the age of people who have Cardiac failure aggravated when taking Nubain? *

What are other drugs people take besides Nubain? *

What are other side effects people have besides Cardiac failure aggravated? *

Fluid Overload (too much fluid in the blood): 5 people, 41.67%
Enlarged Heart: 5 people, 41.67%
Tachypnea: 5 people, 41.67%
Sinus Tachycardia (a heart rhythm with elevated rate of impulses originating from the sinoatrial node): 5 people, 41.67%
Cardiac Murmur (an heart sound in valve abnormality): 5 people, 41.67%
Right Ventricular Hypertrophy (right ventricular enlargement): 5 people, 41.67%
Tricuspid Valve Incompetence (inefficient heart valve): 5 people, 41.67%
Electrocardiogram Qrs Complex Prolonged: 5 people, 41.67%
Drug Exposure During Pregnancy: 5 people, 41.67%
Cardiac Failure Congestive: 4 people, 33.33%

What are the existing conditions these people have? *

Depression: 5 people, 41.67%
Sedation: 2 people, 16.67%
Psychotic Disorder: 1 person, 8.33%
Migraine (headache): 1 person, 8.33%
Mania (a state of abnormally elevated or irritable mood): 1 person, 8.33%
Bipolar I Disorder (mood disorder that is characterized by at least one manic or mixed episode): 1 person, 8.33%
Bipolar Disorder (mood disorder): 1 person, 8.33%
Back Pain: 1 person, 8.33%

* Approximation only. Some reports may have incomplete information.

Do you take Nubain and have Cardiac failure aggravated?

- Check whether Cardiac failure aggravated is associated with a drug or a condition
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Related studies:

Effectiveness of, long term effects of, and alternative drugs to Nubain:

Nubain (1,749 reports)

Browse all side effects of Nubain:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Cardiac failure aggravated:

Cardiac failure aggravated (1,827 drugs)

Browse all the conditions that are associated with Cardiac failure aggravated:

Cardiac failure aggravated (760 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on nalbuphine hydrochloride (the active ingredients of Nubain) and Nubain (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.