Nucynta er and Joint pain - a phase IV clinical study of FDA data

Summary:

Joint pain is reported as a side effect among people who take Nucynta er (tapentadol hydrochloride), especially for people who are female, 60+ old, have been taking the drug for < 1 month also take Lyrica, and have Depression.

The phase IV clinical study analyzes which people have Joint pain when taking Nucynta er. It is created by eHealthMe based on reports of 2,418 people who have side effects when taking Nucynta er from the FDA, and is updated regularly.

What is Nucynta er?

Nucynta er has active ingredients of tapentadol hydrochloride. It is often used in pain. eHealthMe is studying from 2,508 Nucynta er users. Check the latest studies of Nucynta er.

What is Joint pain?

Joint pain is found to be associated with 3,331 drugs and 5,203 conditions by eHealthMe. Check the latest studies of Joint pain.

On Jul, 12, 2026

2,418 people reported to have side effects when taking Nucynta er.
Among them, 23 people (0.95%) have Joint pain.

Among these 23 people:

How long have people been on Nucynta er when they have Joint pain? *

What is the gender of people who have Joint pain when taking Nucynta er? *

female: 68.42 %
male: 31.58 %

What is the age of people who have Joint pain when taking Nucynta er? *

What are other drugs people take besides Nucynta er? *

Xanax: 5 people, 21.74%
Lyrica: 5 people, 21.74%
Dilaudid: 4 people, 17.39%
Nucynta: 4 people, 17.39%
Wellbutrin: 4 people, 17.39%
Cymbalta: 4 people, 17.39%
Clonazepam: 3 people, 13.04%
Nuvigil: 3 people, 13.04%
Diphenhydramine Hydrochloride: 3 people, 13.04%
Neurontin: 3 people, 13.04%

What are other side effects people have besides Joint pain? *

Drug Ineffective: 9 people, 39.13%
Muscle Aches (muscle pain): 6 people, 26.09%
Weakness: 5 people, 21.74%
Nausea (feeling of having an urge to vomit): 5 people, 21.74%
Fatigue (feeling of tiredness): 4 people, 17.39%
Fall: 4 people, 17.39%
Feeling Abnormal: 4 people, 17.39%
Hallucinations (sensations that appear real but are created by your mind): 4 people, 17.39%
Neuropathy Peripheral (surface nerve damage): 4 people, 17.39%
Insomnia (sleeplessness): 4 people, 17.39%

What are the existing conditions these people have? *

Stress And Anxiety: 6 people, 26.09%
Depression: 6 people, 26.09%
Headache (pain in head): 4 people, 17.39%
Sleep Disorder: 4 people, 17.39%
Mental Impairment (a condition affecting the body, perhaps through sight or hearing loss, a mobility difficulty or a health condition): 3 people, 13.04%
Muscle Spasms (muscle contraction): 3 people, 13.04%
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 2 people, 8.70%
Neck Pain: 2 people, 8.70%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 2 people, 8.70%
Hypersensitivity: 2 people, 8.70%

* Approximation only. Some reports may have incomplete information.

Do you take Nucynta er and have Joint pain?

- Check whether Joint pain is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Nucynta er:

Nucynta er (2,508 reports)

Joint pain treatments and more:

Joint pain (542,934 reports)

Browse all side effects of Nucynta er:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Joint pain:

Joint pain (3,331 drugs)

Browse all the conditions that are associated with Joint pain:

Joint pain (5,203 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on tapentadol hydrochloride (the active ingredients of Nucynta er) and Nucynta er (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.