Nucynta and Type 2 diabetes - a phase IV clinical study of FDA data

Summary:

Type 2 diabetes is reported as a side effect among people who take Nucynta (tapentadol hydrochloride), especially for people who are female, 50-59 old, have been taking the drug for 2 - 5 years also take Cymbalta, and have Rheumatoid arthritis.

The phase IV clinical study analyzes which people have Type 2 diabetes when taking Nucynta. It is created by eHealthMe based on reports of 31,342 people who have side effects when taking Nucynta from the FDA, and is updated regularly.

What is Nucynta?

Nucynta has active ingredients of tapentadol hydrochloride. It is often used in pain. eHealthMe is studying from 31,818 Nucynta users. Check the latest studies of Nucynta.

What is Type 2 diabetes?

Type 2 diabetes is found to be associated with 1,431 drugs and 2,346 conditions by eHealthMe. Check the latest studies of Type 2 diabetes.

On Jul, 27, 2026

31,342 people reported to have side effects when taking Nucynta.
Among them, 18 people (0.06%) have Type 2 diabetes.

Among these 18 people:

How long have people been on Nucynta when they have Type 2 diabetes? *

What is the gender of people who have Type 2 diabetes when taking Nucynta? *

female: 86.67 %
male: 13.33 %

What is the age of people who have Type 2 diabetes when taking Nucynta? *

What are other drugs people take besides Nucynta? *

Dilaudid: 12 people, 66.67%
Cymbalta: 12 people, 66.67%
Clonazepam: 11 people, 61.11%
Prevacid: 11 people, 61.11%
Hydrocortisone Valerate: 11 people, 61.11%
Claritin: 11 people, 61.11%
Aripiprazole: 11 people, 61.11%
Cetirizine Hydrochloride: 11 people, 61.11%
Atenolol: 11 people, 61.11%
Famotidine: 11 people, 61.11%

What are other side effects people have besides Type 2 diabetes? *

Diarrhea: 13 people, 72.22%
Fall: 12 people, 66.67%
Drug Hypersensitivity: 12 people, 66.67%
Dizziness: 12 people, 66.67%
Fainting (loss of consciousness and postural tone): 11 people, 61.11%
Fatigue (feeling of tiredness): 11 people, 61.11%
Gastric Ulcer (stomach ulcer): 11 people, 61.11%
Glomerular Filtration Rate Increased: 11 people, 61.11%
Hyperhidrosis (abnormally increased sweating): 11 people, 61.11%
Blood Alkaline Phosphatase Increased: 11 people, 61.11%

What are the existing conditions these people have? *

Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 6 people, 33.33%
Sleep Disorder: 4 people, 22.22%
Hypersensitivity: 4 people, 22.22%
Seizures (abnormal excessive or synchronous neuronal activity in the brain): 1 person, 5.56%
Relapsing-Remitting Multiple Sclerosis (reoccurrence of an inflammatory disease in which the insulating covers of nerve cells in the brain and spinal cord are damaged): 1 person, 5.56%
Psoriatic Arthropathy (inflammation of the skin and joints with kin condition which typically causes patches (plaques) of red, scaly skin to develop): 1 person, 5.56%
Neuralgia (pain in one or more nerves): 1 person, 5.56%
Nerve Injury: 1 person, 5.56%
Nausea (feeling of having an urge to vomit): 1 person, 5.56%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 1 person, 5.56%

* Approximation only. Some reports may have incomplete information.

Do you take Nucynta and have Type 2 diabetes?

- Check whether Type 2 diabetes is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Nucynta:

Nucynta (31,818 reports)

Type 2 diabetes treatments and more:

Type 2 diabetes (391,582 reports)

Browse all side effects of Nucynta:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Type 2 diabetes:

Type 2 diabetes (1,431 drugs)

Browse all the conditions that are associated with Type 2 diabetes:

Type 2 diabetes (2,346 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on tapentadol hydrochloride (the active ingredients of Nucynta) and Nucynta (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.