Nuplazid and Muscle atrophy - a phase IV clinical study of FDA data

Summary:

Muscle atrophy is reported as a side effect among people who take Nuplazid (pimavanserin tartrate), especially for people who are female, 60+ old, have been taking the drug for 6 - 12 months also take Botox, and have Delusion.

The phase IV clinical study analyzes which people have Muscle atrophy when taking Nuplazid. It is created by eHealthMe based on reports of 47,098 people who have side effects when taking Nuplazid from the FDA, and is updated regularly.

What is Nuplazid?

Nuplazid has active ingredients of pimavanserin tartrate. eHealthMe is studying from 47,103 Nuplazid users. Check the latest studies of Nuplazid.

What is Muscle atrophy?

Muscle atrophy (a decrease in the mass of the muscle) is found to be associated with 1,052 drugs and 1,963 conditions by eHealthMe. Check the latest studies of Muscle atrophy.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 11, 2026

47,098 people reported to have side effects when taking Nuplazid.
Among them, 14 people (0.03%) have Muscle atrophy.

Among these 14 people:

How long have people been on Nuplazid when they have Muscle atrophy? *

What is the gender of people who have Muscle atrophy when taking Nuplazid? *

female: 57.14 %
male: 42.86 %

What is the age of people who have Muscle atrophy when taking Nuplazid? *

What are other drugs people take besides Nuplazid? *

Rabeprazole: 5 people, 35.71%
Botox: 5 people, 35.71%
Sinemet: 2 people, 14.29%
Melatonin: 2 people, 14.29%
Depakote: 1 person, 7.14%

What are other side effects people have besides Muscle atrophy? *

Drug Ineffective: 10 people, 71.43%
Gait Disturbance: 7 people, 50.00%
Hallucinations, Mixed (sensations that appear real but are created by your mind -mixed): 6 people, 42.86%
Hallucinations (sensations that appear real but are created by your mind): 5 people, 35.71%
Hallucination, Visual (seeing things that aren't there): 5 people, 35.71%
Confusional State: 5 people, 35.71%
Dysstasia (difficulty in standing): 5 people, 35.71%
Drowsiness: 4 people, 28.57%
Aggression: 4 people, 28.57%
Body Height Decreased: 4 people, 28.57%

What are the existing conditions these people have? *

Hallucinations (sensations that appear real but are created by your mind): 10 people, 71.43%
Delusion (a false belief or opinion): 10 people, 71.43%
Parkinson's Disease: 8 people, 57.14%
Dyskinesia (abnormality or impairment of voluntary movement): 2 people, 14.29%

* Approximation only. Some reports may have incomplete information.

Do you take Nuplazid and have Muscle atrophy?

- Check whether Muscle atrophy is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Nuplazid:

Nuplazid (47,103 reports)

Muscle atrophy treatments and more:

Muscle atrophy (15,319 reports)

Browse all side effects of Nuplazid:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Muscle atrophy:

Muscle atrophy (1,052 drugs)

Browse all the conditions that are associated with Muscle atrophy:

Muscle atrophy (1,963 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on pimavanserin tartrate (the active ingredients of Nuplazid) and Nuplazid (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.