Nuplazid and Muscle rigidity - a phase IV clinical study of FDA data

Summary:

Muscle rigidity is reported as a side effect among people who take Nuplazid (pimavanserin tartrate), especially for people who are male, 60+ old, have been taking the drug for < 1 month also take Sinemet, and have Hallucinations.

The phase IV clinical study analyzes which people have Muscle rigidity when taking Nuplazid. It is created by eHealthMe based on reports of 47,098 people who have side effects when taking Nuplazid from the FDA, and is updated regularly.

What is Nuplazid?

Nuplazid has active ingredients of pimavanserin tartrate. eHealthMe is studying from 47,103 Nuplazid users. Check the latest studies of Nuplazid.

What is Muscle rigidity?

Muscle rigidity (muscle stiffness) is found to be associated with 779 drugs and 1,036 conditions by eHealthMe. Check the latest studies of Muscle rigidity.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 02, 2026

47,098 people reported to have side effects when taking Nuplazid.
Among them, 94 people (0.2%) have Muscle rigidity.

Among these 94 people:

How long have people been on Nuplazid when they have Muscle rigidity? *

What is the gender of people who have Muscle rigidity when taking Nuplazid? *

female: 28.72 %
male: 71.28 %

What is the age of people who have Muscle rigidity when taking Nuplazid? *

What are other drugs people take besides Nuplazid? *

What are other side effects people have besides Muscle rigidity? *

Hallucinations (sensations that appear real but are created by your mind): 32 people, 34.04%
Weakness: 17 people, 18.09%
Confusional State: 17 people, 18.09%
Drug Ineffective: 17 people, 18.09%
Drowsiness: 17 people, 18.09%
Gait Disturbance: 16 people, 17.02%
Musculoskeletal Stiffness (stiffness of the body's muscles, joints, tendons, ligaments and nerves): 15 people, 15.96%
Delusion (a false belief or opinion): 15 people, 15.96%
Tremor (trembling or shaking movements in one or more parts of your body): 13 people, 13.83%
Dysstasia (difficulty in standing): 13 people, 13.83%

What are the existing conditions these people have? *

Hallucinations (sensations that appear real but are created by your mind): 67 people, 71.28%
Delusion (a false belief or opinion): 59 people, 62.77%
Parkinson's Disease: 39 people, 41.49%
Dementia (madness): 5 people, 5.32%
Constipation: 4 people, 4.26%
Tremor (trembling or shaking movements in one or more parts of your body): 3 people, 3.19%
Drooling (drop saliva uncontrollably from the mouth): 2 people, 2.13%
Depression: 2 people, 2.13%
Dementia With Lewy Bodies (progressive degenerative disease or syndrome of the brain): 2 people, 2.13%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 2 people, 2.13%

* Approximation only. Some reports may have incomplete information.

Do you take Nuplazid and have Muscle rigidity?

- Check whether Muscle rigidity is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Nuplazid:

Nuplazid (47,103 reports)

Muscle rigidity treatments and more:

Muscle rigidity (16,888 reports)

Browse all side effects of Nuplazid:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Muscle rigidity:

Muscle rigidity (779 drugs)

Browse all the conditions that are associated with Muscle rigidity:

Muscle rigidity (1,036 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on pimavanserin tartrate (the active ingredients of Nuplazid) and Nuplazid (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.