Nuvaring and Agitation - a phase IV clinical study of FDA data

Summary:

Agitation is reported as a side effect among people who take Nuvaring (ethinyl estradiol; etonogestrel), especially for people who are female, 20-29 old, have been taking the drug for 1 - 6 months also take Valtrex, and have Depression.

The phase IV clinical study analyzes which people have Agitation when taking Nuvaring. It is created by eHealthMe based on reports of 27,664 people who have side effects when taking Nuvaring from the FDA, and is updated regularly.

What is Nuvaring?

Nuvaring has active ingredients of ethinyl estradiol; etonogestrel. It is often used in birth control. eHealthMe is studying from 28,730 Nuvaring users. Check the latest studies of Nuvaring.

What is Agitation?

Agitation (state of anxiety or nervous excitement) is found to be associated with 2,281 drugs and 3,318 conditions by eHealthMe. Check the latest studies of Agitation.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 03, 2026

27,664 people reported to have side effects when taking Nuvaring.
Among them, 72 people (0.26%) have Agitation.

Among these 72 people:

How long have people been on Nuvaring when they have Agitation? *

What is the gender of people who have Agitation when taking Nuvaring? *

female: 98.48 %
male: 1.52 %

What is the age of people who have Agitation when taking Nuvaring? *

What are other drugs people take besides Nuvaring? *

Valtrex: 11 people, 15.28%
Ventolin: 9 people, 12.50%
Xyrem: 7 people, 9.72%
Fioricet: 7 people, 9.72%
Tramadol Hydrochloride And Acetaminophen: 7 people, 9.72%
Adderall: 6 people, 8.33%
Cymbalta: 6 people, 8.33%
Zoloft: 5 people, 6.94%
Glucophage: 5 people, 6.94%
Celexa: 5 people, 6.94%

What are other side effects people have besides Agitation? *

Stress And Anxiety: 32 people, 44.44%
Aggression: 23 people, 31.94%
Pulmonary Embolism (blockage of the main artery of the lung): 19 people, 26.39%
Headache (pain in head): 18 people, 25.00%
Nausea And Vomiting: 17 people, 23.61%
Depression: 15 people, 20.83%
Panic Disorder: 15 people, 20.83%
Hypercoagulation (increased tendency for clotting of the blood): 14 people, 19.44%
Migraine (headache): 14 people, 19.44%
Grand Mal Convulsion (a type of generalized seizure that affects the entire brain): 13 people, 18.06%

What are the existing conditions these people have? *

Depression: 7 people, 9.72%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 6 people, 8.33%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 6 people, 8.33%
Stress And Anxiety: 5 people, 6.94%
Menstruation Irregular: 5 people, 6.94%
Migraine (headache): 3 people, 4.17%
Idiopathic Thrombocytopenic Purpura (bleeding disorder in which the immune system destroys platelets, which are necessary for normal blood clotting): 3 people, 4.17%
Pain: 3 people, 4.17%
Insomnia (sleeplessness): 3 people, 4.17%
Urticaria (rash of round, red welts on the skin that itch intensely): 2 people, 2.78%

* Approximation only. Some reports may have incomplete information.

Do you take Nuvaring and have Agitation?

- Check whether Agitation is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Nuvaring:

Nuvaring (28,730 reports)

Agitation treatments and more:

Agitation (142,109 reports)

How severe was Agitation and when was it recovered:

Agitation in Nuvaring

Expand to all the drugs that have ingredients of ethinyl estradiol; etonogestrel:

Agitation and drugs with ingredients of ethinyl estradiol; etonogestrel (65 reports)

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Nuvaring:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Agitation:

Agitation (2,281 drugs)

Browse all the conditions that are associated with Agitation:

Agitation (3,318 conditions)

Related publications that referenced our studies

Teimoory M, Arefi M, Behnoush B, Bastani B, "Promethazine and Treatment Refractory Agitation in Clonidine Toxicity", International Journal of Medical Toxicology and Forensic Medicine, 2013 Mar .
Teimoory M, Arefi M, Behnoush B, Bastani B, "Promethazine and Treatment Refractory Agitation in Clonidine Toxicity", International Journal of Medical Toxicology and Forensic Medicine, 2013 Mar .

How the study uses the data?

The study uses data from the FDA. It is based on ethinyl estradiol; etonogestrel (the active ingredients of Nuvaring) and Nuvaring (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.