Nyquil and Joint pain - a phase IV clinical study of FDA data

Summary:

Joint pain is reported as a side effect among people who take Nyquil (acetaminophen / dextromethorphan / doxylamine / pseudoephedrine), especially for people who are female, 60+ old, also take Vitamin D3, and have Primary myelofibrosis.

The phase IV clinical study analyzes which people have Joint pain when taking Nyquil. It is created by eHealthMe based on reports of 2,013 people who have side effects when taking Nyquil from the FDA, and is updated regularly.

What is Nyquil?

Nyquil has active ingredients of acetaminophen / dextromethorphan / doxylamine / pseudoephedrine. It is often used in cold symptoms. eHealthMe is studying from 2,240 Nyquil users. Check the latest studies of Nyquil.

What is Joint pain?

Joint pain is found to be associated with 3,331 drugs and 5,204 conditions by eHealthMe. Check the latest studies of Joint pain.

On May, 14, 2026

2,013 people reported to have side effects when taking Nyquil.
Among them, 46 people (2.29%) have Joint pain.

Among these 46 people:

What is the gender of people who have Joint pain when taking Nyquil? *

female: 72.97 %
male: 27.03 %

What is the age of people who have Joint pain when taking Nyquil? *

What are other drugs people take besides Nyquil? *

What are other side effects people have besides Joint pain? *

Fall: 12 people, 26.09%
Pain: 12 people, 26.09%
Fatigue (feeling of tiredness): 10 people, 21.74%
Nasopharyngitis (inflammation of the nasopharynx): 9 people, 19.57%
Abdominal Discomfort: 8 people, 17.39%
Nausea (feeling of having an urge to vomit): 8 people, 17.39%
Pain In Extremity: 8 people, 17.39%
White Blood Cell Count Increased: 8 people, 17.39%
Weakness: 7 people, 15.22%
Flatulence (flatus expelled through the anus): 7 people, 15.22%

What are the existing conditions these people have? *

Pain: 6 people, 13.04%
Primary Myelofibrosis (primary disorder of the bone marrow): 6 people, 13.04%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 5 people, 10.87%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 3 people, 6.52%
Lambert-Eaton Syndrome (this means your immune system mistakenly targets healthy cells and tissues in the body): 3 people, 6.52%
Immunodeficiency Common Variable: 2 people, 4.35%
Depression: 2 people, 4.35%
Crohn's Disease (a condition that causes inflammation of the gastrointestinal tract): 2 people, 4.35%
Panic Disorder: 2 people, 4.35%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 2 people, 4.35%

* Approximation only. Some reports may have incomplete information.

Do you take Nyquil and have Joint pain?

- Check whether Joint pain is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Nyquil:

Nyquil (2,240 reports)

Joint pain treatments and more:

Joint pain (542,934 reports)

How severe was Joint pain and when was it recovered:

Joint pain in Nyquil

Expand to all the drugs that have ingredients of acetaminophen / dextromethorphan / doxylamine / pseudoephedrine:

Joint pain and drugs with ingredients of acetaminophen / dextromethorphan / doxylamine / pseudoephedrine (33 reports)

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Nyquil:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Joint pain:

Joint pain (3,331 drugs)

Browse all the conditions that are associated with Joint pain:

Joint pain (5,204 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on acetaminophen / dextromethorphan / doxylamine / pseudoephedrine (the active ingredients of Nyquil) and Nyquil (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.