Ogen and Apical granuloma - a phase IV clinical study of FDA data

Summary:

Apical granuloma is reported as a side effect among people who take Ogen (estropipate), especially for people who are female, 60+ old, have been taking the drug for 10+ years also take Fosamax, and have Osteoporosis.

The phase IV clinical study analyzes which people have Apical granuloma when taking Ogen. It is created by eHealthMe based on reports of 2,536 people who have side effects when taking Ogen from the FDA, and is updated regularly.

What is Ogen?

Ogen has active ingredients of estropipate. eHealthMe is studying from 2,553 Ogen users. Check the latest studies of Ogen.

What is Apical granuloma?

Apical granuloma (tumour of the apex of a nonvital tooth) is found to be associated with 45 drugs and 52 conditions by eHealthMe. Check the latest studies of Apical granuloma.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 01, 2026

2,536 people reported to have side effects when taking Ogen.
Among them, 11 people (0.43%) have Apical granuloma.

Among these 11 people:

How long have people been on Ogen when they have Apical granuloma? *

What is the gender of people who have Apical granuloma when taking Ogen? *

female: 100 %
male: 0.0 %

What is the age of people who have Apical granuloma when taking Ogen? *

What are other drugs people take besides Ogen? *

Fosamax: 11 people, 100.00%
Boniva: 6 people, 54.55%
Actonel: 6 people, 54.55%

What are other side effects people have besides Apical granuloma? *

Jaw Disorder (jaw disease): 11 people, 100.00%
Tooth Loss: 11 people, 100.00%
Tooth Abscess (pus formation in tooth): 11 people, 100.00%
Gums - Swollen: 11 people, 100.00%
Gingival Bleeding (bleeding gums): 11 people, 100.00%
Fistula (an abnormal connection or passageway between two): 6 people, 54.55%
Urinary Tract Infection Bacterial: 6 people, 54.55%
Impaired Healing: 6 people, 54.55%
High Blood Pressure: 6 people, 54.55%
Gingival Pain (gum pain): 6 people, 54.55%

What are the existing conditions these people have? *

Osteoporosis (bones weak and more likely to break): 11 people, 100.00%
Osteopenia (a condition where bone mineral density is lower than normal): 6 people, 54.55%

* Approximation only. Some reports may have incomplete information.

Do you take Ogen and have Apical granuloma?

- Check whether Apical granuloma is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Ogen:

Ogen (2,553 reports)

Browse all side effects of Ogen:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Apical granuloma:

Apical granuloma (45 drugs)

Browse all the conditions that are associated with Apical granuloma:

Apical granuloma (52 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on estropipate (the active ingredients of Ogen) and Ogen (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.