Ogen and Cannot sleep - a phase IV clinical study of FDA data

Summary:

Cannot sleep is reported as a side effect among people who take Ogen (estropipate), especially for people who are female, 50-59 old, have been taking the drug for 10+ years also take Premarin, and have Rheumatoid arthritis.

The phase IV clinical study analyzes which people have Cannot sleep when taking Ogen. It is created by eHealthMe based on reports of 2,536 people who have side effects when taking Ogen from the FDA, and is updated regularly.

What is Ogen?

Ogen has active ingredients of estropipate. eHealthMe is studying from 2,553 Ogen users. Check the latest studies of Ogen.

What is Cannot sleep?

Cannot sleep is found to be associated with 4,470 drugs and 5,378 conditions by eHealthMe. Check the latest studies of Cannot sleep.

On May, 31, 2026

2,536 people reported to have side effects when taking Ogen.
Among them, 39 people (1.54%) have Cannot sleep.

Among these 39 people:

How long have people been on Ogen when they have Cannot sleep? *

What is the gender of people who have Cannot sleep when taking Ogen? *

female: 100 %
male: 0.0 %

What is the age of people who have Cannot sleep when taking Ogen? *

What are other drugs people take besides Ogen? *

What are other side effects people have besides Cannot sleep? *

Weight Decreased: 21 people, 53.85%
Anaemia (lack of blood): 16 people, 41.03%
Depression: 14 people, 35.90%
Malaise (a feeling of general discomfort or uneasiness): 13 people, 33.33%
Stress And Anxiety: 13 people, 33.33%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 12 people, 30.77%
Gastric Disorder (disease of stomach): 12 people, 30.77%
Weight Increased: 12 people, 30.77%
Abdominal Pain: 11 people, 28.21%
The Flu (the flu is caused by an influenza virus): 11 people, 28.21%

What are the existing conditions these people have? *

Migraine (headache): 12 people, 30.77%
Menopause (end of monthly cycles in women): 12 people, 30.77%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 12 people, 30.77%
Pain: 11 people, 28.21%
Cardiac Disorder: 10 people, 25.64%
Hypersensitivity: 10 people, 25.64%
High Blood Cholesterol: 3 people, 7.69%
Hot Flush (sudden feelings of heat): 3 people, 7.69%
Systemic Lupus Erythematosus (an autoimmune disease, which means the body's immune system mistakenly, attacks healthy tissue): 3 people, 7.69%
Rashes (redness): 3 people, 7.69%

* Approximation only. Some reports may have incomplete information.

Do you take Ogen and have Cannot sleep?

- Check whether Cannot sleep is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Ogen:

Ogen (2,553 reports)

Cannot sleep treatments and more:

Cannot sleep (438,076 reports)

Browse all side effects of Ogen:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Cannot sleep:

Cannot sleep (4,470 drugs)

Browse all the conditions that are associated with Cannot sleep:

Cannot sleep (5,378 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on estropipate (the active ingredients of Ogen) and Ogen (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.