Olive leaf and Fatigue - a phase IV clinical study of FDA data

Summary:

Fatigue is reported as a side effect among people who take Olive leaf (olive), especially for people who are female, 60+ old, have been taking the drug for < 1 month also take Vitamin D3, and have Cataplexy.

The phase IV clinical study analyzes which people have Fatigue when taking Olive leaf. It is created by eHealthMe based on reports of 261 people who have side effects when taking Olive leaf from the FDA, and is updated regularly.

What is Olive leaf?

Olive leaf has active ingredients of olive. eHealthMe is studying from 308 Olive leaf users. Check the latest studies of Olive leaf.

What is Fatigue?

Fatigue (feeling of tiredness) is found to be associated with 4,026 drugs and 6,380 conditions by eHealthMe. Check the latest studies of Fatigue.



On Jul, 18, 2026

261 people reported to have side effects when taking Olive leaf.
Among them, 33 people (12.64%) have Fatigue.

Could Olive leaf cause Fatigue?

Among these 33 people:

How long have people been on Olive leaf when they have Fatigue? *

  • < 1 month: 66.67 %
  • 1 - 6 months: 33.33 %
  • 6 - 12 months: 0.0 %
  • 1 - 2 years: 0.0 %
  • 2 - 5 years: 0.0 %
  • 5 - 10 years: 0.0 %
  • 10+ years: 0.0 %

What is the gender of people who have Fatigue when taking Olive leaf? *

  • female: 87.1 %
  • male: 12.9 %

What is the age of people who have Fatigue when taking Olive leaf? *

  • 0-1: 0.0 %
  • 2-9: 0.0 %
  • 10-19: 0.0 %
  • 20-29: 11.76 %
  • 30-39: 0.0 %
  • 40-49: 29.41 %
  • 50-59: 17.65 %
  • 60+: 41.18 %

What are other drugs people take besides Olive leaf? *

  1. Vitamin D3: 12 people, 36.36%
  2. Fish Oil: 11 people, 33.33%
  3. Vitamin B12: 11 people, 33.33%
  4. Curcumin: 10 people, 30.30%
  5. Coenzyme Q10: 9 people, 27.27%
  6. Tylenol: 8 people, 24.24%
  7. Vitamin C: 8 people, 24.24%
  8. Naltrexone: 8 people, 24.24%
  9. Biotin: 7 people, 21.21%
  10. Vitamin B6: 7 people, 21.21%

What are other side effects people have besides Fatigue? *

  1. Nausea (feeling of having an urge to vomit): 12 people, 36.36%
  2. Dizziness: 11 people, 33.33%
  3. Stress And Anxiety: 11 people, 33.33%
  4. Weakness: 9 people, 27.27%
  5. Tremor (trembling or shaking movements in one or more parts of your body): 9 people, 27.27%
  6. Pain: 9 people, 27.27%
  7. Malaise (a feeling of general discomfort or uneasiness): 8 people, 24.24%
  8. Memory Loss: 8 people, 24.24%
  9. Insomnia (sleeplessness): 6 people, 18.18%
  10. Headache (pain in head): 6 people, 18.18%

What are the existing conditions these people have? *

  1. Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 6 people, 18.18%
  2. Cataplexy (loss of muscle tone accompanied by full conscious awareness): 6 people, 18.18%
  3. Immune System Disorder: 3 people, 9.09%
  4. Immunodeficiency Common Variable: 3 people, 9.09%
  5. Primary Immunodeficiency Syndrome: 2 people, 6.06%
  6. Oestrogen Deficiency (lack of estrogens): 2 people, 6.06%
  7. Multiple Myeloma (cancer of the plasma cells): 2 people, 6.06%
  8. Rickets (softening of bones): 2 people, 6.06%
  9. Chronic Thyroiditis (long lasting inflammation of thyroid gland): 2 people, 6.06%
  10. Chronic Obstructive Pulmonary Disease (a progressive disease that makes it hard to breathe): 1 person, 3.03%

* Approximation only. Some reports may have incomplete information.

Do you take Olive leaf and have Fatigue?

- Check whether Fatigue is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously



Related studies:

Effectiveness of, long term effects of, and alternative drugs to Olive leaf:

Fatigue treatments and more:

How severe was Fatigue and when was it recovered:

Expand to all the drugs that have ingredients of olive:

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Olive leaf:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Fatigue:

Browse all the conditions that are associated with Fatigue:

Related publications that referenced our studies


How the study uses the data?

The study uses data from the FDA. It is based on olive (the active ingredients of Olive leaf) and Olive leaf (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.



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