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Olysio and Constipation - a phase IV clinical study of FDA data

Summary:

Constipation is reported as a side effect among people who take Olysio (simeprevir), especially for people who are female, 60+ old, have been taking the drug for < 1 month also take Sovaldi, and have Hepatitis c.

The phase IV clinical study analyzes which people have Constipation when taking Olysio. It is created by eHealthMe based on reports of 3,074 people who have side effects when taking Olysio from the FDA, and is updated regularly.

What is Olysio?

Olysio has active ingredients of simeprevir. eHealthMe is studying from 3,076 Olysio users. Check the latest studies of Olysio.

What is Constipation?

Constipation is found to be associated with 3,004 drugs and 4,610 conditions by eHealthMe. Check the latest studies of Constipation.

On Jul, 10, 2026

3,074 people reported to have side effects when taking Olysio.
Among them, 24 people (0.78%) have Constipation.

Could Olysio cause Constipation?

Among these 24 people:

How long have people been on Olysio when they have Constipation? *

  • < 1 month: 87.5 %
  • 1 - 6 months: 12.5 %
  • 6 - 12 months: 0.0 %
  • 1 - 2 years: 0.0 %
  • 2 - 5 years: 0.0 %
  • 5 - 10 years: 0.0 %
  • 10+ years: 0.0 %

What is the gender of people who have Constipation when taking Olysio? *

  • female: 58.33 %
  • male: 41.67 %

What is the age of people who have Constipation when taking Olysio? *

  • 0-1: 0.0 %
  • 2-9: 0.0 %
  • 10-19: 0.0 %
  • 20-29: 0.0 %
  • 30-39: 5 %
  • 40-49: 20 %
  • 50-59: 20 %
  • 60+: 55 %

What are other drugs people take besides Olysio? *

  1. Sovaldi: 16 people, 66.67%
  2. Vitamin D3: 3 people, 12.50%
  3. Copegus: 3 people, 12.50%
  4. Sofosbuvir: 2 people, 8.33%
  5. Rebetol: 2 people, 8.33%
  6. Zolpidem: 1 person, 4.17%
  7. Thiamine: 1 person, 4.17%
  8. Synthroid: 1 person, 4.17%
  9. Symbicort: 1 person, 4.17%
  10. Proair Hfa: 1 person, 4.17%

What are other side effects people have besides Constipation? *

  1. Nausea And Vomiting: 6 people, 25.00%
  2. Nausea (feeling of having an urge to vomit): 5 people, 20.83%
  3. Headache (pain in head): 5 people, 20.83%
  4. Fatigue (feeling of tiredness): 4 people, 16.67%
  5. Thrombocytopenia (decrease of platelets in blood): 4 people, 16.67%
  6. Confusional State: 3 people, 12.50%
  7. Hyponatremia (abnormally low level of sodium in the blood; associated with dehydration): 3 people, 12.50%
  8. Haemoglobin Decreased: 3 people, 12.50%
  9. Haemodynamic Instability (disturbances in the blood movement in our body): 3 people, 12.50%
  10. Inflammation: 3 people, 12.50%

What are the existing conditions these people have? *

  1. Hepatitis C: 15 people, 62.50%
  2. Stress And Anxiety: 1 person, 4.17%
  3. Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 1 person, 4.17%
  4. Cyst (a closed sac): 1 person, 4.17%
  5. Ascites (accumulation of fluid in the abdominal cavity): 1 person, 4.17%

* Approximation only. Some reports may have incomplete information.

Do you take Olysio and have Constipation?

- Check whether Constipation is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Olysio:

Constipation treatments and more:

How severe was Constipation and when was it recovered:

Expand to all the drugs that have ingredients of simeprevir:

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Olysio:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Constipation:

Browse all the conditions that are associated with Constipation:

How the study uses the data?

The study uses data from the FDA. It is based on simeprevir (the active ingredients of Olysio) and Olysio (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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