Ondansetron and Diverticular perforation - a phase IV clinical study of FDA data

Summary:

Diverticular perforation is reported as a side effect among people who take Ondansetron (ondansetron), especially for people who are female, 60+ old, have been taking the drug for < 1 month also take Promethazine, and have Constipation.

The phase IV clinical study analyzes which people have Diverticular perforation when taking Ondansetron. It is created by eHealthMe based on reports of 122,217 people who have side effects when taking Ondansetron from the FDA, and is updated regularly.

What is Ondansetron?

Ondansetron has active ingredients of ondansetron. It is often used in nausea. eHealthMe is studying from 122,739 Ondansetron users. Check the latest studies of Ondansetron.

What is Diverticular perforation?

Diverticular perforation (serious gastrointestinal condition in which the intestine's walls are perforated) is found to be associated with 365 drugs and 413 conditions by eHealthMe. Check the latest studies of Diverticular perforation.

On Aug, 11, 2026

122,217 people reported to have side effects when taking Ondansetron.
Among them, 39 people (0.03%) have Diverticular perforation.

Could Ondansetron cause Diverticular perforation?

Among these 39 people:

How long have people been on Ondansetron when they have Diverticular perforation? *

What is the gender of people who have Diverticular perforation when taking Ondansetron? *

female: 51.28 %
male: 48.72 %

What is the age of people who have Diverticular perforation when taking Ondansetron? *

What are other drugs people take besides Ondansetron? *

What are other side effects people have besides Diverticular perforation? *

Diverticulitis (digestive disease which involves the formation of pouches (diverticula) within the bowel wall): 9 people, 23.08%
Agranulocytosis (a deficiency of granulocytes in the blood, causing increased vulnerability to infection): 8 people, 20.51%
Hypophagia (reduced food intake): 7 people, 17.95%
Small Intestinal Obstruction (blockage in small intestine): 7 people, 17.95%
Chills (felling of cold): 7 people, 17.95%
Colitis (inflammation of colon): 7 people, 17.95%
Fever: 7 people, 17.95%
Hypotension (abnormally low blood pressure): 7 people, 17.95%
Large Intestine Perforation (hole in large intestine): 7 people, 17.95%
Thrombocytopenia (decrease of platelets in blood): 5 people, 12.82%

What are the existing conditions these people have? *

Pain: 11 people, 28.21%
Constipation: 11 people, 28.21%
Non-Hodgkin's Lymphoma (malignant (cancer) cells form in the lymph system): 10 people, 25.64%
Cancer Pain: 7 people, 17.95%
Stress And Anxiety: 7 people, 17.95%
High Blood Pressure: 6 people, 15.38%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 5 people, 12.82%
Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 5 people, 12.82%
Febrile Neutropenia (fever with reduced white blood cells): 4 people, 10.26%
Lung Cancer - Non-Small Cell (lung cancer): 4 people, 10.26%

* Approximation only. Some reports may have incomplete information.

Do you take Ondansetron and have Diverticular perforation?

- Check whether Diverticular perforation is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Ondansetron:

Ondansetron (122,739 reports)

Browse all side effects of Ondansetron:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Diverticular perforation:

Diverticular perforation (365 drugs)

Browse all the conditions that are associated with Diverticular perforation:

Diverticular perforation (413 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on ondansetron (the active ingredients of Ondansetron) and Ondansetron (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.