Onpattro and Dyspnea exacerbated - a phase IV clinical study of FDA data

Summary:

Dyspnea exacerbated is reported as a side effect among people who take Onpattro (patisiran), especially for people who are male, 60+ old, have been taking the drug for < 1 month also take Famotidine, and have Hereditary neuropathic amyloidosis.

The phase IV clinical study analyzes which people have Dyspnea exacerbated when taking Onpattro. It is created by eHealthMe based on reports of 2,785 people who have side effects when taking Onpattro from the FDA, and is updated regularly.

What is Onpattro?

Onpattro has active ingredients of patisiran. eHealthMe is studying from 2,785 Onpattro users. Check the latest studies of Onpattro.

What is Dyspnea exacerbated?

Dyspnea exacerbated is found to be associated with 3,343 drugs and 1,659 conditions by eHealthMe. Check the latest studies of Dyspnea exacerbated.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 01, 2026

2,785 people reported to have side effects when taking Onpattro.
Among them, 86 people (3.09%) have Dyspnea exacerbated.

Could Onpattro cause Dyspnea exacerbated?

Among these 86 people:

How long have people been on Onpattro when they have Dyspnea exacerbated? *

What is the gender of people who have Dyspnea exacerbated when taking Onpattro? *

female: 26.92 %
male: 73.08 %

What is the age of people who have Dyspnea exacerbated when taking Onpattro? *

What are other drugs people take besides Onpattro? *

Famotidine: 11 people, 12.79%
Acetaminophen: 9 people, 10.47%
Dexamethasone: 9 people, 10.47%
Lasix: 8 people, 9.30%
Vitamin A: 6 people, 6.98%
Vitamins: 6 people, 6.98%
Novorapid: 5 people, 5.81%
Plavix: 5 people, 5.81%
Lantus: 5 people, 5.81%
Dexamethasone Sodium Phosphate: 4 people, 4.65%

What are other side effects people have besides Dyspnea exacerbated? *

Cardiac Failure: 16 people, 18.60%
Fatigue (feeling of tiredness): 13 people, 15.12%
Weakness: 12 people, 13.95%
Infusion Related Reaction: 8 people, 9.30%
Peripheral Swelling: 7 people, 8.14%
Generalised Oedema (swelling all over the body): 7 people, 8.14%
Stress And Anxiety: 7 people, 8.14%
Oxygen Saturation Decreased: 6 people, 6.98%
Dizziness: 6 people, 6.98%
Face Oedema (swelling of face): 6 people, 6.98%

What are the existing conditions these people have? *

Hereditary Neuropathic Amyloidosis (hereditary- diseases resulting from abnormal deposition of certain proteins (amyloid) in various bodily areas by problems with signals from the nerves): 61 people, 70.93%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 7 people, 8.14%
Diabetes: 7 people, 8.14%
Pain: 6 people, 6.98%
Amyloidosis Senile (common form of amyloidosis in very old people, usually mild and limited to the heart): 6 people, 6.98%
Polyneuropathy (neurological disorder that occurs when many peripheral nerves throughout the body malfunction simultaneously): 5 people, 5.81%
Carotid Arteriosclerosis (plaque deposition in artery): 5 people, 5.81%
Type 2 Diabetes: 5 people, 5.81%
Amyloidosis (a tumour within which amyloid is produced): 4 people, 4.65%
Urination - Excessive Volume: 4 people, 4.65%

* Approximation only. Some reports may have incomplete information.

Do you take Onpattro and have Dyspnea exacerbated?

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Related studies:

Effectiveness of, long term effects of, and alternative drugs to Onpattro:

Onpattro (2,785 reports)

Browse all side effects of Onpattro:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Dyspnea exacerbated:

Dyspnea exacerbated (3,343 drugs)

Browse all the conditions that are associated with Dyspnea exacerbated:

Dyspnea exacerbated (1,659 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on patisiran (the active ingredients of Onpattro) and Onpattro (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.