Onpattro and Seizures - a phase IV clinical study of FDA data

Summary:

Seizures is reported as a side effect among people who take Onpattro (patisiran), especially for people who are male, 60+ old, have been taking the drug for 1 - 6 months also take Polaramine, and have Hereditary neuropathic amyloidosis.

The phase IV clinical study analyzes which people have Seizures when taking Onpattro. It is created by eHealthMe based on reports of 2,785 people who have side effects when taking Onpattro from the FDA, and is updated regularly.

What is Onpattro?

Onpattro has active ingredients of patisiran. eHealthMe is studying from 2,785 Onpattro users. Check the latest studies of Onpattro.

What is Seizures?

Seizures (abnormal excessive or synchronous neuronal activity in the brain) is found to be associated with 1,986 drugs and 2,282 conditions by eHealthMe. Check the latest studies of Seizures.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 03, 2026

2,785 people reported to have side effects when taking Onpattro.
Among them, 36 people (1.29%) have Seizures.

Among these 36 people:

How long have people been on Onpattro when they have Seizures? *

What is the gender of people who have Seizures when taking Onpattro? *

female: 40 %
male: 60 %

What is the age of people who have Seizures when taking Onpattro? *

What are other drugs people take besides Onpattro? *

Polaramine: 16 people, 44.44%
Lyrica: 15 people, 41.67%
Xylocaine: 11 people, 30.56%
Vitamins: 9 people, 25.00%
Cefazolin Sodium: 8 people, 22.22%
Decadron: 8 people, 22.22%
Dexamethasone Sodium Phosphate: 8 people, 22.22%
Famotidine: 8 people, 22.22%
Fexofenadine Hydrochloride: 8 people, 22.22%
Amoxicillin: 8 people, 22.22%

What are other side effects people have besides Seizures? *

Weakness: 15 people, 41.67%
Cardiac Failure: 14 people, 38.89%
Pleural Effusion (water on the lungs): 14 people, 38.89%
Oedema Peripheral (superficial swelling): 14 people, 38.89%
Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 11 people, 30.56%
Neurogenic Bladder (the normal function of the bladder is to store and empty urine in a coordinated, controlled fashion): 11 people, 30.56%
Hypokalemia (low potassium): 10 people, 27.78%
Constipation: 9 people, 25.00%
Ventricular Arrhythmia (problem with the rate or rhythm of the heartbeat): 9 people, 25.00%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 9 people, 25.00%

What are the existing conditions these people have? *

Hereditary Neuropathic Amyloidosis (hereditary- diseases resulting from abnormal deposition of certain proteins (amyloid) in various bodily areas by problems with signals from the nerves): 28 people, 77.78%
Vitamin B1 Deficiency: 11 people, 30.56%
Cardiac Failure: 11 people, 30.56%
Constipation: 11 people, 30.56%
Enterocolitis (inflammation of the digestive tract, involving enteritis of the small intestine and colitis of the colon): 11 people, 30.56%
Diarrhea: 11 people, 30.56%
Hypokalemia (low potassium): 11 people, 30.56%
Hypotension (abnormally low blood pressure): 11 people, 30.56%
Muscle Spasms (muscle contraction): 11 people, 30.56%
Allergic Rhinitis: 11 people, 30.56%

* Approximation only. Some reports may have incomplete information.

Do you take Onpattro and have Seizures?

- Check whether Seizures is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Onpattro:

Onpattro (2,785 reports)

Seizures treatments and more:

Seizures (150,180 reports)

Browse all side effects of Onpattro:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Seizures:

Seizures (1,986 drugs)

Browse all the conditions that are associated with Seizures:

Seizures (2,282 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on patisiran (the active ingredients of Onpattro) and Onpattro (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.