Opdivo and Acute hepatic failure - a phase IV clinical study of FDA data

Summary:

Acute hepatic failure is reported as a side effect among people who take Opdivo (nivolumab), especially for people who are male, 60+ old, have been taking the drug for < 1 month also take Yervoy, and have Renal cell carcinoma.

The phase IV clinical study analyzes which people have Acute hepatic failure when taking Opdivo. It is created by eHealthMe based on reports of 56,294 people who have side effects when taking Opdivo from the FDA, and is updated regularly.

What is Opdivo?

Opdivo has active ingredients of nivolumab. eHealthMe is studying from 56,331 Opdivo users. Check the latest studies of Opdivo.

What is Acute hepatic failure?

Acute hepatic failure is found to be associated with 710 drugs and 1,180 conditions by eHealthMe. Check the latest studies of Acute hepatic failure.

On Jul, 13, 2026

56,294 people reported to have side effects when taking Opdivo.
Among them, 42 people (0.07%) have Acute hepatic failure.

Could Opdivo cause Acute hepatic failure?

Among these 42 people:

How long have people been on Opdivo when they have Acute hepatic failure? *

What is the gender of people who have Acute hepatic failure when taking Opdivo? *

female: 26.19 %
male: 73.81 %

What is the age of people who have Acute hepatic failure when taking Opdivo? *

What are other drugs people take besides Opdivo? *

Yervoy: 23 people, 54.76%
Methylcobalamin: 5 people, 11.90%
Polaramine: 5 people, 11.90%
Dexamethasone Sodium Phosphate: 5 people, 11.90%
Emend: 5 people, 11.90%
Famotidine: 5 people, 11.90%
Matulane: 5 people, 11.90%
Palonosetron: 5 people, 11.90%
Aloxi: 5 people, 11.90%
Avastin: 4 people, 9.52%

What are other side effects people have besides Acute hepatic failure? *

Hepatic Encephalopathy (spectrum of neuropsychiatric abnormalities in patients with liver failure): 11 people, 26.19%
Malignant Neoplasm Progression (cancer tumour came back): 9 people, 21.43%
Drug Eruption (adverse drug reaction of the skin): 7 people, 16.67%
Agranulocytosis (a deficiency of granulocytes in the blood, causing increased vulnerability to infection): 6 people, 14.29%
Anaemia (lack of blood): 6 people, 14.29%
Rectal Haemorrhage (bleeding from anus): 6 people, 14.29%
Eosinophil Count Increased: 5 people, 11.90%
Urinary Tract Infection: 5 people, 11.90%
Deep Venous Thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis): 5 people, 11.90%
Cytomegalovirus Viraemia (cytomegalo virus in blood stream): 5 people, 11.90%

What are the existing conditions these people have? *

Renal Cell Carcinoma (a kidney cancer): 7 people, 16.67%
Malignant Glioma (cancerous tumour of brain a cancer tumour of uncertain origin that arises both in soft tissue and bone): 6 people, 14.29%
Oesophageal Carcinoma (cancer tumour of oesophagus): 6 people, 14.29%
Metastatic Renal Cell Carcinoma (spreadable kidney cell tumour): 6 people, 14.29%
Non-Small Cell Lung Cancer Recurrent (type of epithelial lung cancer reoccurrence): 5 people, 11.90%
Insomnia (sleeplessness): 5 people, 11.90%
Malignant Melanoma (skin cancer rises from melancytes): 4 people, 9.52%
Lung Cancer - Non-Small Cell (lung cancer): 3 people, 7.14%
Squamous Cell Carcinoma (a cancer of a kind of epithelial cell): 2 people, 4.76%
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 1 person, 2.38%

* Approximation only. Some reports may have incomplete information.

Do you take Opdivo and have Acute hepatic failure?

- Check whether Acute hepatic failure is associated with a drug or a condition
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Related studies:

Effectiveness of, long term effects of, and alternative drugs to Opdivo:

Opdivo (56,331 reports)

Browse all side effects of Opdivo:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Acute hepatic failure:

Acute hepatic failure (710 drugs)

Browse all the conditions that are associated with Acute hepatic failure:

Acute hepatic failure (1,180 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on nivolumab (the active ingredients of Opdivo) and Opdivo (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.