Opsumit and Ocular icterus - a phase IV clinical study of FDA data

Summary:

Ocular icterus is reported as a side effect among people who take Opsumit (macitentan), especially for people who are female, 60+ old, have been taking the drug for 1 - 6 months also take Lasix, and have Primary pulmonary hypertension.

The phase IV clinical study analyzes which people have Ocular icterus when taking Opsumit. It is created by eHealthMe based on reports of 67,913 people who have side effects when taking Opsumit from the FDA, and is updated regularly.

What is Opsumit?

Opsumit has active ingredients of macitentan. eHealthMe is studying from 67,926 Opsumit users. Check the latest studies of Opsumit.

What is Ocular icterus?

Ocular icterus (presence of jaundice seen in the sclera of the eye) is found to be associated with 505 drugs and 783 conditions by eHealthMe. Check the latest studies of Ocular icterus.

On Jul, 26, 2026

67,913 people reported to have side effects when taking Opsumit.
Among them, 57 people (0.08%) have Ocular icterus.

Among these 57 people:

How long have people been on Opsumit when they have Ocular icterus? *

What is the gender of people who have Ocular icterus when taking Opsumit? *

female: 87.72 %
male: 12.28 %

What is the age of people who have Ocular icterus when taking Opsumit? *

What are other drugs people take besides Opsumit? *

What are other side effects people have besides Ocular icterus? *

Fatigue (feeling of tiredness): 22 people, 38.60%
Dyspnea (difficult or laboured breathing): 20 people, 35.09%
Appetite - Decreased (decreased appetite occurs when you have a reduced desire to eat): 18 people, 31.58%
Headache (pain in head): 17 people, 29.82%
Pain In Extremity: 16 people, 28.07%
Peripheral Swelling: 15 people, 26.32%
Nausea (feeling of having an urge to vomit): 14 people, 24.56%
Diarrhea: 14 people, 24.56%
Yellow Skin: 13 people, 22.81%
Abdominal Pain Upper: 12 people, 21.05%

What are the existing conditions these people have? *

Primary Pulmonary Hypertension (primary high blood pressure that affects the arteries in the lungs and the right side of your heart): 44 people, 77.19%
Pulmonary Hypertension (increase in blood pressure in the lung artery): 12 people, 21.05%
Pain: 4 people, 7.02%
Oedema (fluid collection in tissue): 4 people, 7.02%
Sarcoidosis (an inflammatory disease that affects multiple organs in the body, but mostly the lungs and lymph glands): 3 people, 5.26%
Atrial Tachycardia (rhythm disturbance that arises in the atria): 2 people, 3.51%
Wheezing (a high-pitched whistling sound made while you breath): 1 person, 1.75%
Systemic Lupus Erythematosus (an autoimmune disease, which means the body's immune system mistakenly, attacks healthy tissue): 1 person, 1.75%
Sputum Increased: 1 person, 1.75%
Portopulmonary Hypertension (coexistence of portal and pulmonary hypertension): 1 person, 1.75%

* Approximation only. Some reports may have incomplete information.

Do you take Opsumit and have Ocular icterus?

- Check whether Ocular icterus is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Opsumit:

Opsumit (67,926 reports)

Ocular icterus treatments and more:

Ocular icterus (5,127 reports)

Browse all side effects of Opsumit:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Ocular icterus:

Ocular icterus (505 drugs)

Browse all the conditions that are associated with Ocular icterus:

Ocular icterus (783 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on macitentan (the active ingredients of Opsumit) and Opsumit (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.