Optivar and Agitation - a phase IV clinical study of FDA data

Summary:

Agitation is reported as a side effect among people who take Optivar (azelastine hydrochloride), especially for people who are male, 60+ old, have been taking the drug for < 1 month also take Megace, and have Muscle spasms.

The phase IV clinical study analyzes which people have Agitation when taking Optivar. It is created by eHealthMe based on reports of 361 people who have side effects when taking Optivar from the FDA, and is updated regularly.

What is Optivar?

Optivar has active ingredients of azelastine hydrochloride. eHealthMe is studying from 367 Optivar users. Check the latest studies of Optivar.

What is Agitation?

Agitation (state of anxiety or nervous excitement) is found to be associated with 2,281 drugs and 3,314 conditions by eHealthMe. Check the latest studies of Agitation.

On Jul, 26, 2026

361 people reported to have side effects when taking Optivar.
Among them, 11 people (3.05%) have Agitation.

Among these 11 people:

How long have people been on Optivar when they have Agitation? *

What is the gender of people who have Agitation when taking Optivar? *

female: 20 %
male: 80 %

What is the age of people who have Agitation when taking Optivar? *

What are other drugs people take besides Optivar? *

What are other side effects people have besides Agitation? *

Confusional State: 10 people, 90.91%
Arrhythmias (irregular heartbeat): 10 people, 90.91%
Weight Decreased: 9 people, 81.82%
Glaucoma (increased fluid pressure in the eye with vision loss): 9 people, 81.82%
Dysaesthesia (abnormal sensation): 9 people, 81.82%
Dyspnea (difficult or laboured breathing): 9 people, 81.82%
Ejection Fraction Decreased (systolic heart failure): 9 people, 81.82%
Enlarged Heart: 9 people, 81.82%
Fainting (loss of consciousness and postural tone): 9 people, 81.82%
Fall: 9 people, 81.82%

What are the existing conditions these people have? *

Toothaches (tooth pain): 9 people, 81.82%
Muscle Spasms (muscle contraction): 9 people, 81.82%
Depression: 4 people, 36.36%
Bone Neoplasm Malignant (cancer of bone): 3 people, 27.27%
Seasonal Allergy (allergic condition due to certain season): 1 person, 9.09%
Pseudomonas Infection (pseudomonas infection is caused by a bacterium, pseudomonas aeruginosa): 1 person, 9.09%
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 1 person, 9.09%
Epilepsy (common and diverse set of chronic neurological disorders characterized by seizures): 1 person, 9.09%
Attention Deficit Hyperactivity Disorder (a chronic condition including attention difficulty, hyperactivity, and impulsiveness): 1 person, 9.09%
Appetite Disorder (abnormal eating habits): 1 person, 9.09%

* Approximation only. Some reports may have incomplete information.

Do you take Optivar and have Agitation?

- Check whether Agitation is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Optivar:

Optivar (367 reports)

Agitation treatments and more:

Agitation (142,107 reports)

Browse all side effects of Optivar:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Agitation:

Agitation (2,281 drugs)

Browse all the conditions that are associated with Agitation:

Agitation (3,314 conditions)

Related publications that referenced our studies

Teimoory M, Arefi M, Behnoush B, Bastani B, "Promethazine and Treatment Refractory Agitation in Clonidine Toxicity", International Journal of Medical Toxicology and Forensic Medicine, 2013 Mar .
Teimoory M, Arefi M, Behnoush B, Bastani B, "Promethazine and Treatment Refractory Agitation in Clonidine Toxicity", International Journal of Medical Toxicology and Forensic Medicine, 2013 Mar .

How the study uses the data?

The study uses data from the FDA. It is based on azelastine hydrochloride (the active ingredients of Optivar) and Optivar (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.