Orfadin and Abdominal pain - a phase IV clinical study of FDA data

Summary:

Abdominal pain is reported as a side effect among people who take Orfadin (nitisinone), especially for people who are male, 10-19 old, have been taking the drug for 2 - 5 years also take Augmentin, and have Tyrosinaemia.

The phase IV clinical study analyzes which people have Abdominal pain when taking Orfadin. It is created by eHealthMe based on reports of 968 people who have side effects when taking Orfadin from the FDA, and is updated regularly.

What is Orfadin?

Orfadin has active ingredients of nitisinone. eHealthMe is studying from 968 Orfadin users. Check the latest studies of Orfadin.

What is Abdominal pain?

Abdominal pain is found to be associated with 3,228 drugs and 5,742 conditions by eHealthMe. Check the latest studies of Abdominal pain.

On Jul, 10, 2026

968 people reported to have side effects when taking Orfadin.
Among them, 27 people (2.79%) have Abdominal pain.

Among these 27 people:

How long have people been on Orfadin when they have Abdominal pain? *

What is the gender of people who have Abdominal pain when taking Orfadin? *

female: 44 %
male: 56 %

What is the age of people who have Abdominal pain when taking Orfadin? *

What are other drugs people take besides Orfadin? *

What are other side effects people have besides Abdominal pain? *

Nausea And Vomiting: 9 people, 33.33%
High Blood Pressure: 5 people, 18.52%
Weakness: 3 people, 11.11%
Testicular Pain (pain in testes): 3 people, 11.11%
Eye Irritation: 3 people, 11.11%
Amino Acid Level Increased: 3 people, 11.11%
Arrhythmias (irregular heartbeat): 3 people, 11.11%
Appetite - Decreased (decreased appetite occurs when you have a reduced desire to eat): 3 people, 11.11%
Neuropathy Peripheral (surface nerve damage): 2 people, 7.41%
Fever: 2 people, 7.41%

What are the existing conditions these people have? *

Tyrosinaemia (tyrosine metabolism resulting in liver and kidney disturbances and mental retardation): 25 people, 92.59%
Amino Acid Metabolism Disorder: 2 people, 7.41%
Pneumonia: 1 person, 3.70%
Inappropriate Antidiuretic Hormone Secretion: 1 person, 3.70%
Hyponatremia (abnormally low level of sodium in the blood; associated with dehydration): 1 person, 3.70%
Epilepsy (common and diverse set of chronic neurological disorders characterized by seizures): 1 person, 3.70%
Alkaptonuria (black urine disease): 1 person, 3.70%

* Approximation only. Some reports may have incomplete information.

Do you take Orfadin and have Abdominal pain?

- Check whether Abdominal pain is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Orfadin:

Orfadin (968 reports)

Abdominal pain treatments and more:

Abdominal pain (286,410 reports)

Browse all side effects of Orfadin:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Abdominal pain:

Abdominal pain (3,228 drugs)

Browse all the conditions that are associated with Abdominal pain:

Abdominal pain (5,742 conditions)

Related publications that referenced our studies

Bhuvan KC, ALrasheedy AA, Ibrahim MI, "A case report from Nepalese community pharmacy on levofloxacin induced severe abdominal pain", Saudi Pharmaceutical Journal, 2013 Jul .
Bhuvan KC, ALrasheedy AA, Ibrahim MI, "A case report from Nepalese community pharmacy on levofloxacin induced severe abdominal pain", Saudi Pharmaceutical Journal, 2013 Jul .

How the study uses the data?

The study uses data from the FDA. It is based on nitisinone (the active ingredients of Orfadin) and Orfadin (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.