Ortho-cept and Depression - a phase IV clinical study of FDA data

Summary:

Depression is reported as a side effect among people who take Ortho-cept (desogestrel; ethinyl estradiol), especially for people who are female, 20-29 old, have been taking the drug for 6 - 12 months also take Accutane, and have Acne.

The phase IV clinical study analyzes which people have Depression when taking Ortho-cept. It is created by eHealthMe based on reports of 361 people who have side effects when taking Ortho-cept from the FDA, and is updated regularly.

What is Ortho-cept?

Ortho-cept has active ingredients of desogestrel; ethinyl estradiol. It is often used in birth control. eHealthMe is studying from 394 Ortho-cept users. Check the latest studies of Ortho-cept.

What is Depression?

Depression is found to be associated with 3,169 drugs and 4,126 conditions by eHealthMe. Check the latest studies of Depression.

On Jul, 27, 2026

361 people reported to have side effects when taking Ortho-cept.
Among them, 28 people (7.76%) have Depression.

Among these 28 people:

How long have people been on Ortho-cept when they have Depression? *

What is the gender of people who have Depression when taking Ortho-cept? *

female: 89.29 %
male: 10.71 %

What is the age of people who have Depression when taking Ortho-cept? *

What are other drugs people take besides Ortho-cept? *

What are other side effects people have besides Depression? *

Weight Decreased: 13 people, 46.43%
Inflammatory Bowel Disease: 11 people, 39.29%
Diarrhea: 11 people, 39.29%
Crohn's Disease (a condition that causes inflammation of the gastrointestinal tract): 11 people, 39.29%
Irritable Bowel Syndrome: 11 people, 39.29%
Intestinal Stenosis (partial obstruction that causes the centre opening of the intestine to become narrower): 9 people, 32.14%
Colitis (inflammation of colon): 9 people, 32.14%
Rectal Haemorrhage (bleeding from anus): 9 people, 32.14%
Oesophageal Ulcer (ulcer of oesophagus): 9 people, 32.14%
Intestinal Haemorrhage (bleeding from intestine): 9 people, 32.14%

What are the existing conditions these people have? *

Acne (skin problems that cause pimples): 4 people, 14.29%
Skin Wrinkling (wrinkle on skin): 3 people, 10.71%
Wound Secretion: 1 person, 3.57%
Stress And Anxiety: 1 person, 3.57%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 1 person, 3.57%
Restless Leg Syndrome (a powerful urge to move your legs): 1 person, 3.57%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 1 person, 3.57%
Limb Injury: 1 person, 3.57%
Deep Venous Thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis): 1 person, 3.57%
Attention Deficit Hyperactivity Disorder (a chronic condition including attention difficulty, hyperactivity, and impulsiveness): 1 person, 3.57%

* Approximation only. Some reports may have incomplete information.

Do you take Ortho-cept and have Depression?

- Check whether Depression is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Ortho-cept:

Ortho-cept (394 reports)

Depression treatments and more:

Depression (652,144 reports)

How severe was Depression and when was it recovered:

Depression in Ortho-cept

Expand to all the drugs that have ingredients of desogestrel; ethinyl estradiol:

Depression and drugs with ingredients of desogestrel; ethinyl estradiol (284 reports)

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Ortho-cept:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Depression:

Depression (3,169 drugs)

Browse all the conditions that are associated with Depression:

Depression (4,126 conditions)

Related publications that referenced our studies

Pang, T., & Gudi, A., "Chest pain following the use of fluvoxamine in depression", Proceedings of Singapore Healthcare, 2018 Jan .
Pang, T., & Gudi, A., "Chest pain following the use of fluvoxamine in depression", Proceedings of Singapore Healthcare, 2018 Jan .

How the study uses the data?

The study uses data from the FDA. It is based on desogestrel; ethinyl estradiol (the active ingredients of Ortho-cept) and Ortho-cept (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.