Ortho tri-cyclen and Gallbladder disease - a phase IV clinical study of FDA data

Summary:

Gallbladder disease is reported as a side effect among people who take Ortho tri-cyclen (ethinyl estradiol; norgestimate), especially for people who are female, 20-29 old, have been taking the drug for 5 - 10 years also take Yaz, and have Pain.

The phase IV clinical study analyzes which people have Gallbladder disease when taking Ortho tri-cyclen. It is created by eHealthMe based on reports of 4,840 people who have side effects when taking Ortho tri-cyclen from the FDA, and is updated regularly.

What is Ortho tri-cyclen?

Ortho tri-cyclen has active ingredients of ethinyl estradiol; norgestimate. It is often used in birth control. eHealthMe is studying from 5,699 Ortho tri-cyclen users. Check the latest studies of Ortho tri-cyclen.

What is Gallbladder disease?

Gallbladder disease is found to be associated with 442 drugs and 1,006 conditions by eHealthMe. Check the latest studies of Gallbladder disease.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Jul, 30, 2026

4,840 people reported to have side effects when taking Ortho tri-cyclen.
Among them, 15 people (0.31%) have Gallbladder disease.

Could Ortho tri-cyclen cause Gallbladder disease?

Among these 15 people:

How long have people been on Ortho tri-cyclen when they have Gallbladder disease? *

What is the gender of people who have Gallbladder disease when taking Ortho tri-cyclen? *

female: 100 %
male: 0.0 %

What is the age of people who have Gallbladder disease when taking Ortho tri-cyclen? *

What are other drugs people take besides Ortho tri-cyclen? *

What are other side effects people have besides Gallbladder disease? *

Cholecystitis Chronic (long lasting infection of gallbladder): 9 people, 60.00%
Abdominal Pain Upper: 8 people, 53.33%
Gallstones (stone formation by bile component): 8 people, 53.33%
Injury: 4 people, 26.67%
Cholecystitis (infection of gallbladder): 4 people, 26.67%
Abdominal Pain: 3 people, 20.00%
Nausea And Vomiting: 3 people, 20.00%
Nausea (feeling of having an urge to vomit): 3 people, 20.00%
Gallbladder Disorder: 3 people, 20.00%
Diarrhea: 2 people, 13.33%

What are the existing conditions these people have? *

Pain: 3 people, 20.00%
Sleep Disorder: 2 people, 13.33%
Premenstrual Syndrome: 2 people, 13.33%
Gastroenteritis (inflammation of stomach and intestine): 2 people, 13.33%
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body): 2 people, 13.33%
Bipolar Disorder (mood disorder): 2 people, 13.33%
Attention Deficit Hyperactivity Disorder (a chronic condition including attention difficulty, hyperactivity, and impulsiveness): 2 people, 13.33%
Asthma: 2 people, 13.33%
Nausea (feeling of having an urge to vomit): 1 person, 6.67%

* Approximation only. Some reports may have incomplete information.

Do you take Ortho tri-cyclen and have Gallbladder disease?

- Check whether Gallbladder disease is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Ortho tri-cyclen:

Ortho tri-cyclen (5,699 reports)

Gallbladder disease treatments and more:

Gallbladder disease (4,101 reports)

How severe was Gallbladder disease and when was it recovered:

Gallbladder disease in Ortho tri-cyclen

Expand to all the drugs that have ingredients of ethinyl estradiol; norgestimate:

Gallbladder disease and drugs with ingredients of ethinyl estradiol; norgestimate (33 reports)

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Ortho tri-cyclen:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Gallbladder disease:

Gallbladder disease (442 drugs)

Browse all the conditions that are associated with Gallbladder disease:

Gallbladder disease (1,006 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on ethinyl estradiol; norgestimate (the active ingredients of Ortho tri-cyclen) and Ortho tri-cyclen (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.