Ortho tri-cyclen and Peripheral coldness - a phase IV clinical study of FDA data

Summary:

Peripheral coldness is reported as a side effect among people who take Ortho tri-cyclen (ethinyl estradiol; norgestimate), especially for people who are female, 30-39 old, also take Nuvaring, and have Pneumonia cytomegaloviral.

The phase IV clinical study analyzes which people have Peripheral coldness when taking Ortho tri-cyclen. It is created by eHealthMe based on reports of 4,840 people who have side effects when taking Ortho tri-cyclen from the FDA, and is updated regularly.

What is Ortho tri-cyclen?

Ortho tri-cyclen has active ingredients of ethinyl estradiol; norgestimate. It is often used in birth control. eHealthMe is studying from 5,699 Ortho tri-cyclen users. Check the latest studies of Ortho tri-cyclen.

What is Peripheral coldness?

Peripheral coldness is found to be associated with 1,078 drugs and 1,154 conditions by eHealthMe. Check the latest studies of Peripheral coldness.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 27, 2026

4,840 people reported to have side effects when taking Ortho tri-cyclen.
Among them, 12 people (0.25%) have Peripheral coldness.

Could Ortho tri-cyclen cause Peripheral coldness?

Among these 12 people:

What is the gender of people who have Peripheral coldness when taking Ortho tri-cyclen? *

female: 100 %
male: 0.0 %

What is the age of people who have Peripheral coldness when taking Ortho tri-cyclen? *

What are other drugs people take besides Ortho tri-cyclen? *

Depo-Medrol: 5 people, 41.67%
Desogen: 5 people, 41.67%
Nuvaring: 5 people, 41.67%
Zofran: 4 people, 33.33%
Zithromax: 4 people, 33.33%
Diazepam: 4 people, 33.33%
Dronabinol: 4 people, 33.33%
Ganciclovir: 4 people, 33.33%
Hydrocodone Bitartrate And Acetaminophen: 4 people, 33.33%
Lansoprazole: 4 people, 33.33%

What are other side effects people have besides Peripheral coldness? *

Upper Respiratory Tract Infection: 7 people, 58.33%
Skin Discoloration: 5 people, 41.67%
Weight Decreased: 5 people, 41.67%
Atrial Tachycardia (rhythm disturbance that arises in the atria): 5 people, 41.67%
Pneumonia: 5 people, 41.67%
Bronchitis (inflammation of the mucous membrane in the bronchial tubes): 5 people, 41.67%
Pulmonary Embolism (blockage of the main artery of the lung): 5 people, 41.67%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 5 people, 41.67%
Shoulder Pain: 4 people, 33.33%
Insomnia (sleeplessness): 4 people, 33.33%

What are the existing conditions these people have? *

Pneumonia Cytomegaloviral (cmv pneumonia is caused by a member of a group of herpes-type viruses): 3 people, 25.00%
Pneumonia: 1 person, 8.33%

* Approximation only. Some reports may have incomplete information.

Do you take Ortho tri-cyclen and have Peripheral coldness?

- Check whether Peripheral coldness is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Ortho tri-cyclen:

Ortho tri-cyclen (5,699 reports)

Peripheral coldness treatments and more:

Peripheral coldness (17,252 reports)

How severe was Peripheral coldness and when was it recovered:

Peripheral coldness in Ortho tri-cyclen

Expand to all the drugs that have ingredients of ethinyl estradiol; norgestimate:

Peripheral coldness and drugs with ingredients of ethinyl estradiol; norgestimate

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Ortho tri-cyclen:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Peripheral coldness:

Peripheral coldness (1,078 drugs)

Browse all the conditions that are associated with Peripheral coldness:

Peripheral coldness (1,154 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on ethinyl estradiol; norgestimate (the active ingredients of Ortho tri-cyclen) and Ortho tri-cyclen (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

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