Osmolex er and Death - a phase IV clinical study of FDA data

Summary:

Death is reported as a side effect among people who take Osmolex er (amantadine hydrochloride), especially for people who are female, 60+ old, have been taking the drug for 1 - 6 months also take Nuplazid, and have Parkinson's disease.

The study is created by eHealthMe based on reports of 782 people who have side effects when taking Osmolex er from the FDA, and is updated regularly.

What is Osmolex er?

Osmolex er has active ingredients of amantadine hydrochloride. eHealthMe is studying from 783 Osmolex er users. Check the latest studies of Osmolex er.

On Jul, 14, 2026

782 people reported to have side effects when taking Osmolex er.
Among them, 58 people (7.42%) died.

Among these 58 people:

How long have people been on Osmolex er when they died? *

What is the gender of people who died when taking Osmolex er? *

female: 51.72 %
male: 48.28 %

What is the age of people who died when taking Osmolex er? *

What are other drugs people take besides Osmolex er? *

What are other side effects people have before they died? *

Wound Infection: 1 person, 1.72%
Vision Blurred: 1 person, 1.72%
Swallowing Difficulty: 1 person, 1.72%
Stroke (sudden death of a portion of the brain cells due to a lack of oxygen): 1 person, 1.72%
Seizures (abnormal excessive or synchronous neuronal activity in the brain): 1 person, 1.72%
Parkinson's Disease: 1 person, 1.72%
Osteomyelitis (infection of bone): 1 person, 1.72%
Hypoaesthesia (reduced sense of touch or sensation): 1 person, 1.72%
High Blood Pressure: 1 person, 1.72%
Headache (pain in head): 1 person, 1.72%

What are the existing conditions these people have? *

Parkinson's Disease: 45 people, 77.59%
Hallucinations (sensations that appear real but are created by your mind): 3 people, 5.17%
Extrapyramidal Disorder (involuntary muscle spasms in the face and neck): 3 people, 5.17%
Dyskinesia (abnormality or impairment of voluntary movement): 3 people, 5.17%
Delusion (a false belief or opinion): 3 people, 5.17%
Tardive Dyskinesia (a disorder that involves involuntary movements): 1 person, 1.72%
On And Off Phenomenon: 1 person, 1.72%

* Approximation only. Some reports may have incomplete information.

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Osmolex er:

Osmolex er (783 reports)

Expand to all the drugs that have ingredients of amantadine hydrochloride:

Death and drugs with ingredients of amantadine hydrochloride (901 reports)

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Osmolex er:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Death:

Death (3,125 drugs)

Browse all the conditions that are associated with Death:

Death (3,686 conditions)

Related publications that referenced our studies

Yang Y, Teja S, Baig K, "Bilateral corneal edema associated with amantadine", Canadian Medical Association Journal, 2015 Oct .
Cattoni J, Parekh R, "Acute respiratory distress syndrome: A rare presentation of amantadine toxicity", The American journal of case reports, 2012 Jan .
Yang Y, Teja S, Baig K, "Bilateral corneal edema associated with amantadine", Canadian Medical Association Journal, 2015 Oct .
Cattoni J, Parekh R, "Acute respiratory distress syndrome: A rare presentation of amantadine toxicity", The American journal of case reports, 2012 Jan .

How the study uses the data?

The study uses data from the FDA. It is based on amantadine hydrochloride (the active ingredients of Osmolex er) and Osmolex er (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.