Otrexup and Fatigue - a phase IV clinical study of FDA data

Summary:

Fatigue is reported as a side effect among people who take Otrexup (methotrexate), especially for people who are female, 50-59 old, have been taking the drug for < 1 month also take Humira, and have Rheumatoid arthritis.

The phase IV clinical study analyzes which people have Fatigue when taking Otrexup. It is created by eHealthMe based on reports of 2,116 people who have side effects when taking Otrexup from the FDA, and is updated regularly.

What is Otrexup?

Otrexup has active ingredients of methotrexate. eHealthMe is studying from 2,154 Otrexup users. Check the latest studies of Otrexup.

What is Fatigue?

Fatigue (feeling of tiredness) is found to be associated with 4,026 drugs and 6,380 conditions by eHealthMe. Check the latest studies of Fatigue.

On Jul, 19, 2026

2,116 people reported to have side effects when taking Otrexup.
Among them, 83 people (3.92%) have Fatigue.

Among these 83 people:

How long have people been on Otrexup when they have Fatigue? *

What is the gender of people who have Fatigue when taking Otrexup? *

female: 74.03 %
male: 25.97 %

What is the age of people who have Fatigue when taking Otrexup? *

What are other drugs people take besides Otrexup? *

What are other side effects people have besides Fatigue? *

Nausea (feeling of having an urge to vomit): 32 people, 38.55%
Diarrhea: 16 people, 19.28%
Nausea And Vomiting: 15 people, 18.07%
Headache (pain in head): 14 people, 16.87%
Pain: 14 people, 16.87%
Malaise (a feeling of general discomfort or uneasiness): 13 people, 15.66%
Joint Pain: 12 people, 14.46%
Appetite - Decreased (decreased appetite occurs when you have a reduced desire to eat): 11 people, 13.25%
Dizziness: 11 people, 13.25%
Drug Ineffective: 9 people, 10.84%

What are the existing conditions these people have? *

Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 44 people, 53.01%
Psoriatic Arthropathy (inflammation of the skin and joints with kin condition which typically causes patches (plaques) of red, scaly skin to develop): 7 people, 8.43%
Crohn's Disease (a condition that causes inflammation of the gastrointestinal tract): 6 people, 7.23%
Juvenile Rheumatoid Arthritis (joint inflammation in children due to systemic disease): 3 people, 3.61%
Dermatitis Atopic (inflammatory, chronically relapsing, non-contagious and pruritic skin disorder): 3 people, 3.61%
Depression: 3 people, 3.61%
Pain: 3 people, 3.61%
Urticaria (rash of round, red welts on the skin that itch intensely): 2 people, 2.41%
High Blood Pressure: 2 people, 2.41%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 2 people, 2.41%

* Approximation only. Some reports may have incomplete information.

Do you take Otrexup and have Fatigue?

- Check whether Fatigue is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Otrexup:

Otrexup (2,154 reports)

Fatigue treatments and more:

Fatigue (967,537 reports)

Browse all side effects of Otrexup:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Fatigue:

Fatigue (4,026 drugs)

Browse all the conditions that are associated with Fatigue:

Fatigue (6,380 conditions)

Related publications that referenced our studies

Mathai, P. C., Andrade, N. N., Aggarwal, N., Nerurkar, S., & Kapoor, P. , "Low-dose methotrexate in rheumatoid arthritis: a potential risk factor for bisphosphonate-induced osteonecrosis of the jaw", Oral and maxillofacial surgery, 2018 Jan .
Peel MM, Cooke M, Lewis-Peel HJ, Lea RA, Moyle W, "A randomized controlled trial of coenzyme Q 10 for fatigue in the late-onset sequelae of poliomyelitis", Complementary therapies in medicine, 2015 Dec .
Mathai, P. C., Andrade, N. N., Aggarwal, N., Nerurkar, S., & Kapoor, P. , "Low-dose methotrexate in rheumatoid arthritis: a potential risk factor for bisphosphonate-induced osteonecrosis of the jaw", Oral and maxillofacial surgery, 2018 Jan .
Peel MM, Cooke M, Lewis-Peel HJ, Lea RA, Moyle W, "A randomized controlled trial of coenzyme Q 10 for fatigue in the late-onset sequelae of poliomyelitis", Complementary therapies in medicine, 2015 Dec .

How the study uses the data?

The study uses data from the FDA. It is based on methotrexate (the active ingredients of Otrexup) and Otrexup (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.