Otrexup and Injection site haemorrhage - a phase IV clinical study of FDA data

Summary:

Injection site haemorrhage is reported as a side effect among people who take Otrexup (methotrexate), especially for people who are female, 60+ old, have been taking the drug for 1 - 6 months also take Humira, and have Rheumatoid arthritis.

The phase IV clinical study analyzes which people have Injection site haemorrhage when taking Otrexup. It is created by eHealthMe based on reports of 2,116 people who have side effects when taking Otrexup from the FDA, and is updated regularly.

What is Otrexup?

Otrexup has active ingredients of methotrexate. eHealthMe is studying from 2,154 Otrexup users. Check the latest studies of Otrexup.

What is Injection site haemorrhage?

Injection site haemorrhage (bleeding from injection site) is found to be associated with 1,113 drugs and 1,135 conditions by eHealthMe. Check the latest studies of Injection site haemorrhage.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 02, 2026

2,116 people reported to have side effects when taking Otrexup.
Among them, 29 people (1.37%) have Injection site haemorrhage.

Could Otrexup cause Injection site haemorrhage?

Among these 29 people:

How long have people been on Otrexup when they have Injection site haemorrhage? *

What is the gender of people who have Injection site haemorrhage when taking Otrexup? *

female: 85.71 %
male: 14.29 %

What is the age of people who have Injection site haemorrhage when taking Otrexup? *

What are other drugs people take besides Otrexup? *

What are other side effects people have besides Injection site haemorrhage? *

Injection Site Bruising: 5 people, 17.24%
Injection Site Pain: 3 people, 10.34%
Pain: 3 people, 10.34%
Injection Site Swelling: 2 people, 6.90%
Injection Site Scab: 2 people, 6.90%
Fatigue (feeling of tiredness): 2 people, 6.90%
Injection Site Pruritus (severe itching at injection site): 1 person, 3.45%
Injection Site Injury: 1 person, 3.45%
Injection Site Induration: 1 person, 3.45%
Injection Site Erythema (redness at injection site): 1 person, 3.45%

What are the existing conditions these people have? *

Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 22 people, 75.86%
Depression: 2 people, 6.90%
Uveitis (inflammation of the uvea): 1 person, 3.45%
High Blood Pressure: 1 person, 3.45%
Anaemia (lack of blood): 1 person, 3.45%
Asthma: 1 person, 3.45%
Attention Deficit Hyperactivity Disorder (a chronic condition including attention difficulty, hyperactivity, and impulsiveness): 1 person, 3.45%
Crohn's Disease (a condition that causes inflammation of the gastrointestinal tract): 1 person, 3.45%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 1 person, 3.45%
High Blood Cholesterol: 1 person, 3.45%

* Approximation only. Some reports may have incomplete information.

Do you take Otrexup and have Injection site haemorrhage?

- Check whether Injection site haemorrhage is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Otrexup:

Otrexup (2,154 reports)

Browse all side effects of Otrexup:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Injection site haemorrhage:

Injection site haemorrhage (1,113 drugs)

Browse all the conditions that are associated with Injection site haemorrhage:

Injection site haemorrhage (1,135 conditions)

Related publications that referenced our studies

Mathai, P. C., Andrade, N. N., Aggarwal, N., Nerurkar, S., & Kapoor, P. , "Low-dose methotrexate in rheumatoid arthritis: a potential risk factor for bisphosphonate-induced osteonecrosis of the jaw", Oral and maxillofacial surgery, 2018 Jan .
Mathai, P. C., Andrade, N. N., Aggarwal, N., Nerurkar, S., & Kapoor, P. , "Low-dose methotrexate in rheumatoid arthritis: a potential risk factor for bisphosphonate-induced osteonecrosis of the jaw", Oral and maxillofacial surgery, 2018 Jan .

How the study uses the data?

The study uses data from the FDA. It is based on methotrexate (the active ingredients of Otrexup) and Otrexup (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.