Otrexup and Musculoskeletal stiffness - a phase IV clinical study of FDA data

Summary:

Musculoskeletal stiffness is reported as a side effect among people who take Otrexup (methotrexate), especially for people who are female, 60+ old, also take Enbrel, and have Rheumatoid arthritis.

The phase IV clinical study analyzes which people have Musculoskeletal stiffness when taking Otrexup. It is created by eHealthMe based on reports of 2,116 people who have side effects when taking Otrexup from the FDA, and is updated regularly.

What is Otrexup?

Otrexup has active ingredients of methotrexate. eHealthMe is studying from 2,154 Otrexup users. Check the latest studies of Otrexup.

What is Musculoskeletal stiffness?

Musculoskeletal stiffness (stiffness of the body's muscles, joints, tendons, ligaments and nerves) is found to be associated with 1,959 drugs and 1,917 conditions by eHealthMe. Check the latest studies of Musculoskeletal stiffness.

On Jul, 08, 2026

2,116 people reported to have side effects when taking Otrexup.
Among them, 16 people (0.76%) have Musculoskeletal stiffness.

Could Otrexup cause Musculoskeletal stiffness?

Among these 16 people:

What is the gender of people who have Musculoskeletal stiffness when taking Otrexup? *

female: 81.25 %
male: 18.75 %

What is the age of people who have Musculoskeletal stiffness when taking Otrexup? *

What are other drugs people take besides Otrexup? *

What are other side effects people have besides Musculoskeletal stiffness? *

Joint Pain: 12 people, 75.00%
Pain In Extremity: 9 people, 56.25%
Joint Swelling: 8 people, 50.00%
Joint Stiffness: 7 people, 43.75%
Spinal Pain (pain in spine): 7 people, 43.75%
Urinary Tract Infection: 7 people, 43.75%
Musculoskeletal Pain (pain affects the bones, muscles, ligaments, tendons, and nerves): 5 people, 31.25%
Muscle Aches (muscle pain): 5 people, 31.25%
Drug Ineffective: 4 people, 25.00%
Oral Disorder (mouth disease): 4 people, 25.00%

What are the existing conditions these people have? *

Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 8 people, 50.00%
Type 2 Diabetes: 1 person, 6.25%
Psoriatic Arthropathy (inflammation of the skin and joints with kin condition which typically causes patches (plaques) of red, scaly skin to develop): 1 person, 6.25%
Neuropathy Peripheral (surface nerve damage): 1 person, 6.25%
Hypersensitivity: 1 person, 6.25%

* Approximation only. Some reports may have incomplete information.

Do you take Otrexup and have Musculoskeletal stiffness?

- Check whether Musculoskeletal stiffness is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Otrexup:

Otrexup (2,154 reports)

Browse all side effects of Otrexup:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Musculoskeletal stiffness:

Musculoskeletal stiffness (1,959 drugs)

Browse all the conditions that are associated with Musculoskeletal stiffness:

Musculoskeletal stiffness (1,917 conditions)

Related publications that referenced our studies

Mathai, P. C., Andrade, N. N., Aggarwal, N., Nerurkar, S., & Kapoor, P. , "Low-dose methotrexate in rheumatoid arthritis: a potential risk factor for bisphosphonate-induced osteonecrosis of the jaw", Oral and maxillofacial surgery, 2018 Jan .
Mathai, P. C., Andrade, N. N., Aggarwal, N., Nerurkar, S., & Kapoor, P. , "Low-dose methotrexate in rheumatoid arthritis: a potential risk factor for bisphosphonate-induced osteonecrosis of the jaw", Oral and maxillofacial surgery, 2018 Jan .

How the study uses the data?

The study uses data from the FDA. It is based on methotrexate (the active ingredients of Otrexup) and Otrexup (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.