Oxycodone and acetaminophen and Demyelinating polyneuropathy - a phase IV clinical study of FDA data

Summary:

Demyelinating polyneuropathy is reported as a side effect among people who take Oxycodone and acetaminophen (acetaminophen; oxycodone hydrochloride), especially for people who are female, 40-49 old, also take Remicade, and have Rheumatoid arthritis.

The phase IV clinical study analyzes which people have Demyelinating polyneuropathy when taking Oxycodone and acetaminophen. It is created by eHealthMe based on reports of 13,404 people who have side effects when taking Oxycodone and acetaminophen from the FDA, and is updated regularly.

What is Oxycodone and acetaminophen?

Oxycodone and acetaminophen has active ingredients of acetaminophen; oxycodone hydrochloride. It is often used in pain. eHealthMe is studying from 14,467 Oxycodone and acetaminophen users. Check the latest studies of Oxycodone and acetaminophen.

What is Demyelinating polyneuropathy?

Demyelinating polyneuropathy (disorder that affects the nerves outside of the brain and spinal cord (peripheral nerves)) is found to be associated with 202 drugs and 284 conditions by eHealthMe. Check the latest studies of Demyelinating polyneuropathy.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 29, 2026

13,404 people reported to have side effects when taking Oxycodone and acetaminophen.
Among them, 13 people (0.1%) have Demyelinating polyneuropathy.

Could Oxycodone and acetaminophen cause Demyelinating polyneuropathy?

Among these 13 people:

What is the gender of people who have Demyelinating polyneuropathy when taking Oxycodone and acetaminophen? *

female: 100 %
male: 0.0 %

What is the age of people who have Demyelinating polyneuropathy when taking Oxycodone and acetaminophen? *

What are other drugs people take besides Oxycodone and acetaminophen? *

What are other side effects people have besides Demyelinating polyneuropathy? *

Anaemia (lack of blood): 13 people, 100.00%
Guillain-Barre Syndrome (the body's immune system attacks its peripheral nervous system): 13 people, 100.00%
Thoracic Outlet Syndrome (pain in the arm, shoulder, and neck. it happens when the nerves or blood vessels just below your neck are compressed): 13 people, 100.00%
Neurogenic Bladder (the normal function of the bladder is to store and empty urine in a coordinated, controlled fashion): 13 people, 100.00%
Kidney Infection (Pyelonephritis): 13 people, 100.00%
Drug Ineffective: 12 people, 92.31%
Urinary Tract Infection: 12 people, 92.31%
Chronic Obstructive Pulmonary Disease (a progressive disease that makes it hard to breathe): 12 people, 92.31%
Suicidal Ideation: 9 people, 69.23%
Fall: 9 people, 69.23%

What are the existing conditions these people have? *

Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 13 people, 100.00%
Restless Leg Syndrome (a powerful urge to move your legs): 11 people, 84.62%

* Approximation only. Some reports may have incomplete information.

Do you take Oxycodone and acetaminophen and have Demyelinating polyneuropathy?

- Check whether Demyelinating polyneuropathy is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Oxycodone and acetaminophen:

Oxycodone and acetaminophen (14,467 reports)

Demyelinating polyneuropathy treatments and more:

Demyelinating polyneuropathy (1,579 reports)

How severe was Demyelinating polyneuropathy and when was it recovered:

Demyelinating polyneuropathy in Oxycodone and acetaminophen

Expand to all the drugs that have ingredients of acetaminophen; oxycodone hydrochloride:

Demyelinating polyneuropathy and drugs with ingredients of acetaminophen; oxycodone hydrochloride

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Oxycodone and acetaminophen:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Demyelinating polyneuropathy:

Demyelinating polyneuropathy (202 drugs)

Browse all the conditions that are associated with Demyelinating polyneuropathy:

Demyelinating polyneuropathy (284 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on acetaminophen; oxycodone hydrochloride (the active ingredients of Oxycodone and acetaminophen) and Oxycodone and acetaminophen (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.