Oxycodone and acetaminophen and Hepatic failure - a phase IV clinical study of FDA data

Summary:

Hepatic failure is reported as a side effect among people who take Oxycodone and acetaminophen (acetaminophen; oxycodone hydrochloride), especially for people who are male, 50-59 old, have been taking the drug for 10+ years also take Percocet, and have Cancer pain.

The phase IV clinical study analyzes which people have Hepatic failure when taking Oxycodone and acetaminophen. It is created by eHealthMe based on reports of 13,404 people who have side effects when taking Oxycodone and acetaminophen from the FDA, and is updated regularly.

What is Oxycodone and acetaminophen?

Oxycodone and acetaminophen has active ingredients of acetaminophen; oxycodone hydrochloride. It is often used in pain. eHealthMe is studying from 14,467 Oxycodone and acetaminophen users. Check the latest studies of Oxycodone and acetaminophen.

What is Hepatic failure?

Hepatic failure (liver failure) is found to be associated with 1,539 drugs and 1,894 conditions by eHealthMe. Check the latest studies of Hepatic failure.

On Aug, 08, 2026

13,404 people reported to have side effects when taking Oxycodone and acetaminophen.
Among them, 11 people (0.08%) have Hepatic failure.

Could Oxycodone and acetaminophen cause Hepatic failure?

Among these 11 people:

How long have people been on Oxycodone and acetaminophen when they have Hepatic failure? *

What is the gender of people who have Hepatic failure when taking Oxycodone and acetaminophen? *

female: 20 %
male: 80 %

What is the age of people who have Hepatic failure when taking Oxycodone and acetaminophen? *

What are other drugs people take besides Oxycodone and acetaminophen? *

What are other side effects people have besides Hepatic failure? *

Acute Kidney Failure: 3 people, 27.27%
Haematemesis (vomiting of blood): 2 people, 18.18%
Drug Toxicity: 2 people, 18.18%
Cardio-Respiratory Arrest (sudden dysfunction of heart and lungs): 2 people, 18.18%
Ischaemic Hepatitis (decreased blood supply to the liver resulting in injury to liver cells): 2 people, 18.18%
Bleeding Disorders: 2 people, 18.18%
Drug Dependence: 2 people, 18.18%
Aspartate Aminotransferase Increased: 2 people, 18.18%
Hypotension (abnormally low blood pressure): 2 people, 18.18%
Alanine Aminotransferase Increased: 2 people, 18.18%

What are the existing conditions these people have? *

Cancer Pain: 2 people, 18.18%
Urinary Retention (the inability to completely or partially empty the bladder): 1 person, 9.09%
Type 2 Diabetes: 1 person, 9.09%
Burkitt Lymphoma (cancer of the lymphatic system): 1 person, 9.09%
Diabetes: 1 person, 9.09%
Dyspnea (difficult or laboured breathing): 1 person, 9.09%
Electrolyte Imbalance: 1 person, 9.09%
Fluid Retention (an abnormal accumulation of fluid in the blood): 1 person, 9.09%
Gastric Ulcer (stomach ulcer): 1 person, 9.09%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 1 person, 9.09%

* Approximation only. Some reports may have incomplete information.

Do you take Oxycodone and acetaminophen and have Hepatic failure?

- Check whether Hepatic failure is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Oxycodone and acetaminophen:

Oxycodone and acetaminophen (14,467 reports)

Hepatic failure treatments and more:

Hepatic failure (44,058 reports)

How severe was Hepatic failure and when was it recovered:

Hepatic failure in Oxycodone and acetaminophen

Expand to all the drugs that have ingredients of acetaminophen; oxycodone hydrochloride:

Hepatic failure and drugs with ingredients of acetaminophen; oxycodone hydrochloride

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Oxycodone and acetaminophen:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Hepatic failure:

Hepatic failure (1,539 drugs)

Browse all the conditions that are associated with Hepatic failure:

Hepatic failure (1,894 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on acetaminophen; oxycodone hydrochloride (the active ingredients of Oxycodone and acetaminophen) and Oxycodone and acetaminophen (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.