Oxycodone and acetaminophen and Infusion site extravasation - a phase IV clinical study of FDA data

Summary:

Infusion site extravasation is reported as a side effect among people who take Oxycodone and acetaminophen (acetaminophen; oxycodone hydrochloride), especially for people who are female, 60+ old, also take Epinephrine, and have Immunodeficiency common variable.

The phase IV clinical study analyzes which people have Infusion site extravasation when taking Oxycodone and acetaminophen. It is created by eHealthMe based on reports of 13,404 people who have side effects when taking Oxycodone and acetaminophen from the FDA, and is updated regularly.

What is Oxycodone and acetaminophen?

Oxycodone and acetaminophen has active ingredients of acetaminophen; oxycodone hydrochloride. It is often used in pain. eHealthMe is studying from 14,467 Oxycodone and acetaminophen users. Check the latest studies of Oxycodone and acetaminophen.

What is Infusion site extravasation?

Infusion site extravasation (flow of (blood or lymph) from infusion site) is found to be associated with 649 drugs and 589 conditions by eHealthMe. Check the latest studies of Infusion site extravasation.

On Jul, 11, 2026

13,404 people reported to have side effects when taking Oxycodone and acetaminophen.
Among them, 22 people (0.16%) have Infusion site extravasation.

Could Oxycodone and acetaminophen cause Infusion site extravasation?

Among these 22 people:

What is the gender of people who have Infusion site extravasation when taking Oxycodone and acetaminophen? *

female: 54.55 %
male: 45.45 %

What is the age of people who have Infusion site extravasation when taking Oxycodone and acetaminophen? *

What are other drugs people take besides Oxycodone and acetaminophen? *

Acetaminophen: 17 people, 77.27%
Epinephrine: 17 people, 77.27%
Sodium Chloride: 15 people, 68.18%
Vitamin D3: 11 people, 50.00%
Lidocaine: 10 people, 45.45%
Gabapentin: 10 people, 45.45%
Prednisone: 9 people, 40.91%
Albuterol Sulfate: 8 people, 36.36%
Diphenhydramine Hydrochloride: 8 people, 36.36%
Heparin: 8 people, 36.36%

What are other side effects people have besides Infusion site extravasation? *

Pain In Extremity: 11 people, 50.00%
Fall: 10 people, 45.45%
Fatigue (feeling of tiredness): 9 people, 40.91%
Limb Injury: 8 people, 36.36%
Joint Pain: 7 people, 31.82%
Headache (pain in head): 7 people, 31.82%
Infusion Site Swelling: 6 people, 27.27%
Weakness: 5 people, 22.73%
Upper Respiratory Tract Infection: 5 people, 22.73%
Nasopharyngitis (inflammation of the nasopharynx): 5 people, 22.73%

What are the existing conditions these people have? *

Immunodeficiency Common Variable: 9 people, 40.91%
Myasthenia Gravis (a chronic condition that causes muscles to tire and weaken easily): 3 people, 13.64%
Dermatomyositis (inflammation of the skin and underlying muscle tissue, typically occurring as an autoimmune condition or associated with internal cancer): 3 people, 13.64%
Cellulitis (infection under the skin): 3 people, 13.64%
Primary Immunodeficiency Syndrome: 2 people, 9.09%
Combined Immunodeficiency: 2 people, 9.09%
Chronic Inflammatory Demyelinating Polyradiculoneuropathy (long lasting infection of nerves outside brain and spinal cord): 2 people, 9.09%
Multifocal Motor Neuropathy (a progressively worsening condition where muscles in the extremities gradually weaken): 1 person, 4.55%
Immunodeficiency: 1 person, 4.55%
Bacteraemia (presence of bacteria in the blood): 1 person, 4.55%

* Approximation only. Some reports may have incomplete information.

Do you take Oxycodone and acetaminophen and have Infusion site extravasation?

- Check whether Infusion site extravasation is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Oxycodone and acetaminophen:

Oxycodone and acetaminophen (14,467 reports)

Infusion site extravasation treatments and more:

Infusion site extravasation (8,010 reports)

How severe was Infusion site extravasation and when was it recovered:

Infusion site extravasation in Oxycodone and acetaminophen

Expand to all the drugs that have ingredients of acetaminophen; oxycodone hydrochloride:

Infusion site extravasation and drugs with ingredients of acetaminophen; oxycodone hydrochloride (94 reports)

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Oxycodone and acetaminophen:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Infusion site extravasation:

Infusion site extravasation (649 drugs)

Browse all the conditions that are associated with Infusion site extravasation:

Infusion site extravasation (589 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on acetaminophen; oxycodone hydrochloride (the active ingredients of Oxycodone and acetaminophen) and Oxycodone and acetaminophen (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.