Oxycodone and acetaminophen and Mental disorder - a phase IV clinical study of FDA data

Summary:

Mental disorder is reported as a side effect among people who take Oxycodone and acetaminophen (acetaminophen; oxycodone hydrochloride), especially for people who are male, 50-59 old, have been taking the drug for 2 - 5 years also take Hydrocodone Bitartrate And Acetaminophen, and have Psychotic disorder.

The phase IV clinical study analyzes which people have Mental disorder when taking Oxycodone and acetaminophen. It is created by eHealthMe based on reports of 13,404 people who have side effects when taking Oxycodone and acetaminophen from the FDA, and is updated regularly.

What is Oxycodone and acetaminophen?

Oxycodone and acetaminophen has active ingredients of acetaminophen; oxycodone hydrochloride. It is often used in pain. eHealthMe is studying from 14,467 Oxycodone and acetaminophen users. Check the latest studies of Oxycodone and acetaminophen.

What is Mental disorder?

Mental disorder (a psychological term for a mental or behavioural pattern or anomaly that causes distress or disability) is found to be associated with 1,653 drugs and 1,712 conditions by eHealthMe. Check the latest studies of Mental disorder.

On Jul, 20, 2026

13,404 people reported to have side effects when taking Oxycodone and acetaminophen.
Among them, 56 people (0.42%) have Mental disorder.

Could Oxycodone and acetaminophen cause Mental disorder?

Among these 56 people:

How long have people been on Oxycodone and acetaminophen when they have Mental disorder? *

What is the gender of people who have Mental disorder when taking Oxycodone and acetaminophen? *

female: 40.38 %
male: 59.62 %

What is the age of people who have Mental disorder when taking Oxycodone and acetaminophen? *

What are other drugs people take besides Oxycodone and acetaminophen? *

Hydrocodone Bitartrate And Acetaminophen: 22 people, 39.29%
Oxycontin: 17 people, 30.36%
Percocet: 15 people, 26.79%
Oxycodone Hydrochloride: 12 people, 21.43%
Oxycodone: 10 people, 17.86%
Morphine Sulfate: 8 people, 14.29%
Ibuprofen: 8 people, 14.29%
Dilaudid: 8 people, 14.29%
Ms Contin: 6 people, 10.71%
Vicodin: 6 people, 10.71%

What are other side effects people have besides Mental disorder? *

Depression: 18 people, 32.14%
Stress And Anxiety: 18 people, 32.14%
Drug Dependence: 18 people, 32.14%
Overdose: 12 people, 21.43%
Ill-Defined Disorder: 10 people, 17.86%
Memory Loss: 10 people, 17.86%
Cardiac Disorder: 8 people, 14.29%
Withdrawal Syndrome (a discontinuation syndrome is a set of symptoms occurred due to discontinuation of substance): 8 people, 14.29%
Post-Traumatic Stress Disorder: 7 people, 12.50%
Fatigue (feeling of tiredness): 7 people, 12.50%

What are the existing conditions these people have? *

Wheezing (a high-pitched whistling sound made while you breath): 2 people, 3.57%
Parkinson's Disease: 2 people, 3.57%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 2 people, 3.57%
Delusion (a false belief or opinion): 2 people, 3.57%
Drowsiness: 2 people, 3.57%
Hallucinations (sensations that appear real but are created by your mind): 2 people, 3.57%
Multifocal Motor Neuropathy (a progressively worsening condition where muscles in the extremities gradually weaken): 2 people, 3.57%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 2 people, 3.57%
Abdominal Pain: 2 people, 3.57%
Psychotic Disorder: 2 people, 3.57%

* Approximation only. Some reports may have incomplete information.

Do you take Oxycodone and acetaminophen and have Mental disorder?

- Check whether Mental disorder is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Oxycodone and acetaminophen:

Oxycodone and acetaminophen (14,467 reports)

Mental disorder treatments and more:

Mental disorder (60,610 reports)

How severe was Mental disorder and when was it recovered:

Mental disorder in Oxycodone and acetaminophen

Expand to all the drugs that have ingredients of acetaminophen; oxycodone hydrochloride:

Mental disorder and drugs with ingredients of acetaminophen; oxycodone hydrochloride (1,190 reports)

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Oxycodone and acetaminophen:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Mental disorder:

Mental disorder (1,653 drugs)

Browse all the conditions that are associated with Mental disorder:

Mental disorder (1,712 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on acetaminophen; oxycodone hydrochloride (the active ingredients of Oxycodone and acetaminophen) and Oxycodone and acetaminophen (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.