Oxycodone hydrochloride and Large intestine perforation - a phase IV clinical study of FDA data

Summary:

Large intestine perforation is reported as a side effect among people who take Oxycodone hydrochloride (oxycodone hydrochloride), especially for people who are female, 60+ old, have been taking the drug for 1 - 6 months also take Fentanyl, and have Depression.

The phase IV clinical study analyzes which people have Large intestine perforation when taking Oxycodone hydrochloride. It is created by eHealthMe based on reports of 36,410 people who have side effects when taking Oxycodone hydrochloride from the FDA, and is updated regularly.

What is Oxycodone hydrochloride?

Oxycodone hydrochloride has active ingredients of oxycodone hydrochloride. It is often used in pain. eHealthMe is studying from 36,817 Oxycodone hydrochloride users. Check the latest studies of Oxycodone hydrochloride.

What is Large intestine perforation?

Large intestine perforation (hole in large intestine) is found to be associated with 638 drugs and 794 conditions by eHealthMe. Check the latest studies of Large intestine perforation.

On Jul, 14, 2026

36,410 people reported to have side effects when taking Oxycodone hydrochloride.
Among them, 15 people (0.04%) have Large intestine perforation.

Could Oxycodone hydrochloride cause Large intestine perforation?

Among these 15 people:

How long have people been on Oxycodone hydrochloride when they have Large intestine perforation? *

What is the gender of people who have Large intestine perforation when taking Oxycodone hydrochloride? *

female: 60 %
male: 40 %

What is the age of people who have Large intestine perforation when taking Oxycodone hydrochloride? *

What are other drugs people take besides Oxycodone hydrochloride? *

What are other side effects people have besides Large intestine perforation? *

Constipation: 8 people, 53.33%
Sepsis (a severe blood infection that can lead to organ failure and death): 6 people, 40.00%
Faecalith (hard mass of fecal matter): 4 people, 26.67%
Peritonitis (inflammation of the peritoneum, the thin tissue that lines the inner wall of the abdomen and covers most of the abdominal organs): 4 people, 26.67%
Shock Haemorrhagic (a life-threatening condition with symptoms like low blood pressure, weakness, shallow breathing, cold, clammy skin due to excess bleeding): 3 people, 20.00%
Pneumonia Aspiration (bronchopneumonia that develops due to the entrance of foreign materials into the bronchial tree): 3 people, 20.00%
Jugular Vein Thrombosis (clot in jugular vein): 3 people, 20.00%
Chest Pain: 2 people, 13.33%
General Physical Health Deterioration (weak health status): 2 people, 13.33%
Heart Attack: 2 people, 13.33%

What are the existing conditions these people have? *

Nausea (feeling of having an urge to vomit): 5 people, 33.33%
Depression: 5 people, 33.33%
Spinal Pain (pain in spine): 4 people, 26.67%
Insomnia (sleeplessness): 4 people, 26.67%
Thrombosis (formation of a blood clot inside a blood vessel): 3 people, 20.00%
Conjunctivitis (pink eye): 3 people, 20.00%
Constipation: 3 people, 20.00%
Fever: 3 people, 20.00%
Hepatic Encephalopathy (spectrum of neuropsychiatric abnormalities in patients with liver failure): 3 people, 20.00%
Blood Iron Decreased: 2 people, 13.33%

* Approximation only. Some reports may have incomplete information.

Do you take Oxycodone hydrochloride and have Large intestine perforation?

- Check whether Large intestine perforation is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Oxycodone hydrochloride:

Oxycodone hydrochloride (36,817 reports)

Browse all side effects of Oxycodone hydrochloride:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Large intestine perforation:

Large intestine perforation (638 drugs)

Browse all the conditions that are associated with Large intestine perforation:

Large intestine perforation (794 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on oxycodone hydrochloride (the active ingredients of Oxycodone hydrochloride) and Oxycodone hydrochloride (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.