Oxycodone and Compartment syndrome - a phase IV clinical study of FDA data

Summary:

Compartment syndrome is reported as a side effect among people who take Oxycodone (oxycodone hydrochloride), especially for people who are male, 30-39 old, have been taking the drug for < 1 month also take Codeine, and have High blood pressure.

The phase IV clinical study analyzes which people have Compartment syndrome when taking Oxycodone. It is created by eHealthMe based on reports of 159,853 people who have side effects when taking Oxycodone from the FDA, and is updated regularly.

What is Oxycodone?

Oxycodone has active ingredients of oxycodone hydrochloride. It is often used in pain. eHealthMe is studying from 162,592 Oxycodone users. Check the latest studies of Oxycodone.

What is Compartment syndrome?

Compartment syndrome (painful condition that occurs when pressure within the muscles builds to dangerous levels) is found to be associated with 295 drugs and 427 conditions by eHealthMe. Check the latest studies of Compartment syndrome.

On Jul, 15, 2026

159,853 people reported to have side effects when taking Oxycodone.
Among them, 92 people (0.06%) have Compartment syndrome.

Could Oxycodone cause Compartment syndrome?

Among these 92 people:

How long have people been on Oxycodone when they have Compartment syndrome? *

What is the gender of people who have Compartment syndrome when taking Oxycodone? *

female: 38.89 %
male: 61.11 %

What is the age of people who have Compartment syndrome when taking Oxycodone? *

What are other drugs people take besides Oxycodone? *

What are other side effects people have besides Compartment syndrome? *

Overdose: 33 people, 35.87%
Rhabdomyolysis (a condition in which damaged skeletal muscle tissue breaks down): 25 people, 27.17%
Loss Of Consciousness: 24 people, 26.09%
Acute Kidney Failure: 17 people, 18.48%
Unresponsive To Stimuli: 14 people, 15.22%
Hyperhidrosis (abnormally increased sweating): 12 people, 13.04%
Sinus Tachycardia (a heart rhythm with elevated rate of impulses originating from the sinoatrial node): 12 people, 13.04%
Increased Bronchial Secretion: 10 people, 10.87%
Miosis (constriction of the pupil of the eye, resulting from a normal response to an increase in light): 10 people, 10.87%
Drowsiness: 9 people, 9.78%

What are the existing conditions these people have? *

High Blood Pressure: 6 people, 6.52%
Depression: 5 people, 5.43%
Schizophrenia (a mental disorder characterized by a breakdown of thought processes): 5 people, 5.43%
Constipation: 5 people, 5.43%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 5 people, 5.43%
Psoriatic Arthropathy (inflammation of the skin and joints with kin condition which typically causes patches (plaques) of red, scaly skin to develop): 4 people, 4.35%
Psoriasis (immune-mediated disease that affects the skin): 4 people, 4.35%
Hypersensitivity: 3 people, 3.26%
Phantom Pain: 3 people, 3.26%
Diabetes: 3 people, 3.26%

* Approximation only. Some reports may have incomplete information.

Do you take Oxycodone and have Compartment syndrome?

- Check whether Compartment syndrome is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Oxycodone:

Oxycodone (162,592 reports)

Browse all side effects of Oxycodone:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Compartment syndrome:

Compartment syndrome (295 drugs)

Browse all the conditions that are associated with Compartment syndrome:

Compartment syndrome (427 conditions)

Related publications that referenced our studies

Ray RK, Bashir MA, Rao S, "Co-Administration of Risperidone and Sodium Valproate Causing Bilateral Chronic Exertional Lower Leg Compartment Syndrome", Open Journal of Orthopedics, 2014 Apr .
Ray RK, Bashir MA, Rao S, "Co-Administration of Risperidone and Sodium Valproate Causing Bilateral Chronic Exertional Lower Leg Compartment Syndrome", Open Journal of Orthopedics, 2014 Apr .

How the study uses the data?

The study uses data from the FDA. It is based on oxycodone hydrochloride (the active ingredients of Oxycodone) and Oxycodone (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.