Oxycodone and Edema - a phase IV clinical study of FDA data

Summary:

Edema is reported as a side effect among people who take Oxycodone (oxycodone hydrochloride), especially for people who are female, 40-49 old, have been taking the drug for < 1 month also take Actemra, and have Rheumatoid arthritis.

The phase IV clinical study analyzes which people have Edema when taking Oxycodone. It is created by eHealthMe based on reports of 159,853 people who have side effects when taking Oxycodone from the FDA, and is updated regularly.

What is Oxycodone?

Oxycodone has active ingredients of oxycodone hydrochloride. It is often used in pain. eHealthMe is studying from 162,592 Oxycodone users. Check the latest studies of Oxycodone.

What is Edema?

Edema (excess of watery fluid collecting in the cavities or tissues of the body) is found to be associated with 2,301 drugs and 2,862 conditions by eHealthMe. Check the latest studies of Edema.

On Dec, 24, 2025

159,853 people reported to have side effects when taking Oxycodone.
Among them, 4,155 people (2.6%) have Edema.

Among these 4,155 people:

How long have people been on Oxycodone when they have Edema? *

What is the gender of people who have Edema when taking Oxycodone? *

female: 87.43 %
male: 12.57 %

What is the age of people who have Edema when taking Oxycodone? *

What are other drugs people take besides Oxycodone? *

What are other side effects people have besides Edema? *

Fatigue (feeling of tiredness): 3,067 people, 73.81%
Rashes (redness): 3,060 people, 73.65%
Joint Pain: 3,007 people, 72.37%
Weight Increased: 2,862 people, 68.88%
Impaired Healing: 2,851 people, 68.62%
Drug Ineffective: 2,832 people, 68.16%
Joint Swelling: 2,814 people, 67.73%
Stomatitis (inflammation of mucous membrane of mouth): 2,809 people, 67.61%
Nasopharyngitis (inflammation of the nasopharynx): 2,802 people, 67.44%
Irritable Bowel Syndrome: 2,795 people, 67.27%

What are the existing conditions these people have? *

Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 3,138 people, 75.52%
Psoriatic Arthropathy (inflammation of the skin and joints with kin condition which typically causes patches (plaques) of red, scaly skin to develop): 756 people, 18.19%
Psoriasis (immune-mediated disease that affects the skin): 433 people, 10.42%
Systemic Lupus Erythematosus (an autoimmune disease, which means the body's immune system mistakenly, attacks healthy tissue): 342 people, 8.23%
Stress And Anxiety: 218 people, 5.25%
Crohn's Disease (a condition that causes inflammation of the gastrointestinal tract): 211 people, 5.08%
Arthritis (form of joint disorder that involves inflammation of one or more joints): 182 people, 4.38%
Ankylosing Spondylitis (type of arthritis affecting the spine): 178 people, 4.28%
Fever: 150 people, 3.61%
Multiple Myeloma (cancer of the plasma cells): 149 people, 3.59%

* Approximation only. Some reports may have incomplete information.

Do you take Oxycodone and have Edema?

- Check whether Edema is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Oxycodone:

Oxycodone (162,592 reports)

Edema treatments and more:

Edema (115,734 reports)

Browse all side effects of Oxycodone:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Edema:

Edema (2,301 drugs)

Browse all the conditions that are associated with Edema:

Edema (2,862 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on oxycodone hydrochloride (the active ingredients of Oxycodone) and Oxycodone (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.