Oxycodone and Flat affect - a phase IV clinical study of FDA data

Summary:

Flat affect is reported as a side effect among people who take Oxycodone (oxycodone hydrochloride), especially for people who are female, 50-59 old, have been taking the drug for 2 - 5 years also take Oxycontin, and have Chronic graft versus host disease.

The phase IV clinical study analyzes which people have Flat affect when taking Oxycodone. It is created by eHealthMe based on reports of 159,853 people who have side effects when taking Oxycodone from the FDA, and is updated regularly.

What is Oxycodone?

Oxycodone has active ingredients of oxycodone hydrochloride. It is often used in pain. eHealthMe is studying from 162,581 Oxycodone users. Check the latest studies of Oxycodone.

What is Flat affect?

Flat affect (absence of emotional response to a situation) is found to be associated with 326 drugs and 454 conditions by eHealthMe. Check the latest studies of Flat affect.

On Sep, 12, 2025

159,853 people reported to have side effects when taking Oxycodone.
Among them, 33 people (0.02%) have Flat affect.

Among these 33 people:

How long have people been on Oxycodone when they have Flat affect? *

What is the gender of people who have Flat affect when taking Oxycodone? *

female: 75 %
male: 25 %

What is the age of people who have Flat affect when taking Oxycodone? *

What are other drugs people take besides Oxycodone? *

What are other side effects people have besides Flat affect? *

Depression: 24 people, 72.73%
Confusional State: 20 people, 60.61%
Drug Dependence: 20 people, 60.61%
Stress And Anxiety: 19 people, 57.58%
Fatigue (feeling of tiredness): 18 people, 54.55%
Drug Withdrawal Syndrome (interfere with normal social, occupational, or other functioning. are not due to another medical condition, drug use, or discontinuation): 17 people, 51.52%
Pain In Extremity: 16 people, 48.48%
Weight Decreased: 16 people, 48.48%
Suicidal Ideation: 15 people, 45.45%
Nausea (feeling of having an urge to vomit): 15 people, 45.45%

What are the existing conditions these people have? *

Ulcerative Colitis (inflammatory bowel disease (ibd). it causes swelling, ulcerations, and loss of function of the large intestine): 1 person, 3.03%
Small For Dates Baby (an unborn baby is growing more slowly and is smaller than most babies are at the same age): 1 person, 3.03%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 1 person, 3.03%
Prostate Cancer Metastatic: 1 person, 3.03%
Nausea (feeling of having an urge to vomit): 1 person, 3.03%
Multiple Myeloma (cancer of the plasma cells): 1 person, 3.03%
Hepatitis C: 1 person, 3.03%
Gait Disturbance: 1 person, 3.03%
Chronic Graft Versus Host Disease (immune cells attack the host's body cells after transplant): 1 person, 3.03%

* Approximation only. Some reports may have incomplete information.

Do you take Oxycodone and have Flat affect?

- Check whether Flat affect is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Oxycodone:

Oxycodone (162,581 reports)

Flat affect treatments and more:

Flat affect (2,784 reports)

How severe was Flat affect and when was it recovered:

Flat affect in Oxycodone

Browse all side effects of Oxycodone:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Flat affect:

Flat affect (326 drugs)

Browse all the conditions that are associated with Flat affect:

Flat affect (454 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on oxycodone hydrochloride (the active ingredients of Oxycodone) and Oxycodone (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.