Oxycodone and Gastric perforation - a phase IV clinical study of FDA data

Summary:

Gastric perforation is reported as a side effect among people who take Oxycodone (oxycodone hydrochloride), especially for people who are male, 60+ old, have been taking the drug for 1 - 6 months also take Allopurinol, and have Multiple myeloma.

The phase IV clinical study analyzes which people have Gastric perforation when taking Oxycodone. It is created by eHealthMe based on reports of 159,853 people who have side effects when taking Oxycodone from the FDA, and is updated regularly.

What is Oxycodone?

Oxycodone has active ingredients of oxycodone hydrochloride. It is often used in pain. eHealthMe is studying from 162,592 Oxycodone users. Check the latest studies of Oxycodone.

What is Gastric perforation?

Gastric perforation (hole in stomach) is found to be associated with 304 drugs and 429 conditions by eHealthMe. Check the latest studies of Gastric perforation.

On Jul, 13, 2026

159,853 people reported to have side effects when taking Oxycodone.
Among them, 31 people (0.02%) have Gastric perforation.

Could Oxycodone cause Gastric perforation?

Among these 31 people:

How long have people been on Oxycodone when they have Gastric perforation? *

What is the gender of people who have Gastric perforation when taking Oxycodone? *

female: 40 %
male: 60 %

What is the age of people who have Gastric perforation when taking Oxycodone? *

What are other drugs people take besides Oxycodone? *

Allopurinol: 11 people, 35.48%
Acetaminophen: 10 people, 32.26%
Cyclophosphamide: 10 people, 32.26%
Dexamethasone: 9 people, 29.03%
Carfilzomib: 8 people, 25.81%
Meloxicam: 8 people, 25.81%
Lenalidomide: 8 people, 25.81%
Valacyclovir Hydrochloride: 8 people, 25.81%
Ciprofloxacin: 8 people, 25.81%
Melphalan: 7 people, 22.58%

What are other side effects people have besides Gastric perforation? *

Drug Ineffective: 6 people, 19.35%
Nausea And Vomiting: 5 people, 16.13%
Fall: 4 people, 12.90%
Insomnia (sleeplessness): 4 people, 12.90%
Gastric Ulcer (stomach ulcer): 4 people, 12.90%
Nausea (feeling of having an urge to vomit): 3 people, 9.68%
Deep Venous Thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis): 3 people, 9.68%
Splenomegaly (enlargement of spleen): 3 people, 9.68%
Haematochezia (passage of stools containing blood): 3 people, 9.68%
Ascites (accumulation of fluid in the abdominal cavity): 3 people, 9.68%

What are the existing conditions these people have? *

Multiple Myeloma (cancer of the plasma cells): 8 people, 25.81%
Leukaemia (blood or bone marrow cancer): 7 people, 22.58%
Ovarian Cancer (cancer of ovary): 7 people, 22.58%
Non-Hodgkin's Lymphoma (malignant (cancer) cells form in the lymph system): 5 people, 16.13%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 4 people, 12.90%
High Blood Pressure: 3 people, 9.68%
Abdominal Pain Upper: 2 people, 6.45%
Nerve Injury: 2 people, 6.45%
Indigestion: 2 people, 6.45%
Enlarged Prostate: 2 people, 6.45%

* Approximation only. Some reports may have incomplete information.

Do you take Oxycodone and have Gastric perforation?

- Check whether Gastric perforation is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Oxycodone:

Oxycodone (162,592 reports)

Browse all side effects of Oxycodone:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Gastric perforation:

Gastric perforation (304 drugs)

Browse all the conditions that are associated with Gastric perforation:

Gastric perforation (429 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on oxycodone hydrochloride (the active ingredients of Oxycodone) and Oxycodone (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.