Oxycodone and Hypersomnia - a phase IV clinical study of FDA data

Summary:

Hypersomnia is reported as a side effect among people who take Oxycodone (oxycodone hydrochloride), especially for people who are female, 60+ old, have been taking the drug for < 1 month also take Oxycontin, and have High blood pressure.

The phase IV clinical study analyzes which people have Hypersomnia when taking Oxycodone. It is created by eHealthMe based on reports of 159,853 people who have side effects when taking Oxycodone from the FDA, and is updated regularly.

What is Oxycodone?

Oxycodone has active ingredients of oxycodone hydrochloride. It is often used in pain. eHealthMe is studying from 162,583 Oxycodone users. Check the latest studies of Oxycodone.

What is Hypersomnia?

Hypersomnia (excessive daytime sleepiness (eds)) is found to be associated with 3,155 drugs and 4,781 conditions by eHealthMe. Check the latest studies of Hypersomnia.



On Oct, 05, 2025

159,853 people reported to have side effects when taking Oxycodone.
Among them, 3,719 people (2.33%) have Hypersomnia.

Could Oxycodone cause Hypersomnia?

Among these 3,719 people:

How long have people been on Oxycodone when they have Hypersomnia? *

  • < 1 month: 70.61 %
  • 1 - 6 months: 16.33 %
  • 6 - 12 months: 2.45 %
  • 1 - 2 years: 1.63 %
  • 2 - 5 years: 5.71 %
  • 5 - 10 years: 2.04 %
  • 10+ years: 1.22 %

What is the gender of people who have Hypersomnia when taking Oxycodone? *

  • female: 55.06 %
  • male: 44.94 %

What is the age of people who have Hypersomnia when taking Oxycodone? *

  • 0-1: 0.97 %
  • 2-9: 0.64 %
  • 10-19: 2.11 %
  • 20-29: 5.48 %
  • 30-39: 9.13 %
  • 40-49: 14.26 %
  • 50-59: 22.21 %
  • 60+: 45.2 %

What are other drugs people take besides Oxycodone? *

  1. Oxycontin: 510 people, 13.71%
  2. Acetaminophen: 347 people, 9.33%
  3. Lyrica: 312 people, 8.39%
  4. Gabapentin: 306 people, 8.23%
  5. Morphine: 303 people, 8.15%
  6. Aspirin: 232 people, 6.24%
  7. Metformin: 203 people, 5.46%
  8. Morphine Sulfate: 199 people, 5.35%
  9. Omeprazole: 196 people, 5.27%
  10. Furosemide: 193 people, 5.19%

What are other side effects people have besides Hypersomnia? *

  1. Fatigue (feeling of tiredness): 1,192 people, 32.05%
  2. Nausea (feeling of having an urge to vomit): 714 people, 19.20%
  3. Dizziness: 600 people, 16.13%
  4. Confusional State: 556 people, 14.95%
  5. Headache (pain in head): 523 people, 14.06%
  6. Stress And Anxiety: 519 people, 13.96%
  7. Weakness: 473 people, 12.72%
  8. Drug Ineffective: 467 people, 12.56%
  9. Diarrhea: 448 people, 12.05%
  10. Depression: 438 people, 11.78%

What are the existing conditions these people have? *

  1. High Blood Pressure: 213 people, 5.73%
  2. Cancer Pain: 165 people, 4.44%
  3. Stress And Anxiety: 148 people, 3.98%
  4. High Blood Cholesterol: 145 people, 3.90%
  5. Depression: 144 people, 3.87%
  6. Breakthrough Pain: 134 people, 3.60%
  7. Diabetes: 124 people, 3.33%
  8. Neuralgia (pain in one or more nerves): 121 people, 3.25%
  9. Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 109 people, 2.93%
  10. Nausea (feeling of having an urge to vomit): 100 people, 2.69%

* Approximation only. Some reports may have incomplete information.

Do you take Oxycodone and have Hypersomnia?

- Check whether Hypersomnia is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously



Related studies:

Effectiveness of, long term effects of, and alternative drugs to Oxycodone:

Hypersomnia treatments and more:

How severe was Hypersomnia and when was it recovered:

Expand to all the drugs that have ingredients of oxycodone hydrochloride:

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Common Oxycodone side effects:

Browse all side effects of Oxycodone:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Common drugs associated with Hypersomnia:

Browse all the drugs that are associated with Hypersomnia:

Common conditions associated with Hypersomnia:

Browse all the conditions that are associated with Hypersomnia:

Drugs similar to Oxycodone and Hypersomnia :


How the study uses the data?

The study uses data from the FDA. It is based on oxycodone hydrochloride (the active ingredients of Oxycodone) and Oxycodone (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.



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