Oxycodone and Negative thoughts - a phase IV clinical study of FDA data

Summary:

Negative thoughts is reported as a side effect among people who take Oxycodone (oxycodone hydrochloride), especially for people who are female, 60+ old, have been taking the drug for < 1 month also take Ms Contin, and have Fibromyalgia.

The phase IV clinical study analyzes which people have Negative thoughts when taking Oxycodone. It is created by eHealthMe based on reports of 159,853 people who have side effects when taking Oxycodone from the FDA, and is updated regularly.

What is Oxycodone?

Oxycodone has active ingredients of oxycodone hydrochloride. It is often used in pain. eHealthMe is studying from 162,592 Oxycodone users. Check the latest studies of Oxycodone.

What is Negative thoughts?

Negative thoughts is found to be associated with 241 drugs and 408 conditions by eHealthMe. Check the latest studies of Negative thoughts.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 24, 2026

159,853 people reported to have side effects when taking Oxycodone.
Among them, 22 people (0.01%) have Negative thoughts.

Could Oxycodone cause Negative thoughts?

Among these 22 people:

How long have people been on Oxycodone when they have Negative thoughts? *

What is the gender of people who have Negative thoughts when taking Oxycodone? *

female: 68.18 %
male: 31.82 %

What is the age of people who have Negative thoughts when taking Oxycodone? *

What are other drugs people take besides Oxycodone? *

What are other side effects people have besides Negative thoughts? *

Feeling Abnormal: 8 people, 36.36%
High Blood Pressure: 6 people, 27.27%
Tachyarrhythmia (disturbance of the heart rhythm in which the heart rate is abnormally increased): 6 people, 27.27%
Stress And Anxiety: 5 people, 22.73%
Weakness: 5 people, 22.73%
Loss Of Consciousness: 4 people, 18.18%
Neuralgia (pain in one or more nerves): 4 people, 18.18%
Morbid Thoughts (serious thoughts): 3 people, 13.64%
Pneumonia: 3 people, 13.64%
Hyperaesthesia: 3 people, 13.64%

What are the existing conditions these people have? *

Fibromyalgia (a long-term condition which causes pain all over the body): 7 people, 31.82%
Spinal Stenosis (narrowing of spinal column): 6 people, 27.27%
Bladder Cancer Stage Iv: 3 people, 13.64%
Metastatic Carcinoma Of The Bladder (cancer types can spread to the bladder from other place): 3 people, 13.64%
Anaesthesia: 2 people, 9.09%
Depression: 2 people, 9.09%
Transitional Cell Cancer Of Renal Pelvis And Ureter Metastatic (a cancer of inner most layer of renal pelvis and ureter spreads to other part): 1 person, 4.55%
Bladder Transitional Cell Carcinoma (types of bladder cancer): 1 person, 4.55%
Breakthrough Pain: 1 person, 4.55%
Crohn's Disease (a condition that causes inflammation of the gastrointestinal tract): 1 person, 4.55%

* Approximation only. Some reports may have incomplete information.

Do you take Oxycodone and have Negative thoughts?

- Check whether Negative thoughts is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Oxycodone:

Oxycodone (162,592 reports)

Browse all side effects of Oxycodone:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Negative thoughts:

Negative thoughts (241 drugs)

Browse all the conditions that are associated with Negative thoughts:

Negative thoughts (408 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on oxycodone hydrochloride (the active ingredients of Oxycodone) and Oxycodone (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.