Oxycontin and Muscle rigidity - a phase IV clinical study of FDA data

Summary:

Muscle rigidity is reported as a side effect among people who take Oxycontin (oxycodone hydrochloride), especially for people who are female, 60+ old, have been taking the drug for < 1 month also take Neurontin, and have Depression.

The phase IV clinical study analyzes which people have Muscle rigidity when taking Oxycontin. It is created by eHealthMe based on reports of 210,595 people who have side effects when taking Oxycontin from the FDA, and is updated regularly.

What is Oxycontin?

Oxycontin has active ingredients of oxycodone hydrochloride. It is often used in pain. eHealthMe is studying from 212,533 Oxycontin users. Check the latest studies of Oxycontin.

What is Muscle rigidity?

Muscle rigidity (muscle stiffness) is found to be associated with 784 drugs and 1,035 conditions by eHealthMe. Check the latest studies of Muscle rigidity.

On Jul, 29, 2026

210,595 people reported to have side effects when taking Oxycontin.
Among them, 45 people (0.02%) have Muscle rigidity.

Among these 45 people:

How long have people been on Oxycontin when they have Muscle rigidity? *

What is the gender of people who have Muscle rigidity when taking Oxycontin? *

female: 57.14 %
male: 42.86 %

What is the age of people who have Muscle rigidity when taking Oxycontin? *

What are other drugs people take besides Oxycontin? *

What are other side effects people have besides Muscle rigidity? *

Confusional State: 9 people, 20.00%
Neuroleptic Malignant Syndrome (a life-threatening neurological disorder most often caused by an adverse reaction to neuroleptic or antipsychotic agents): 8 people, 17.78%
Weakness: 7 people, 15.56%
Dyspnea (difficult or laboured breathing): 7 people, 15.56%
Drug Dependence: 6 people, 13.33%
Blood Creatine Phosphokinase Increased: 6 people, 13.33%
Stress And Anxiety: 6 people, 13.33%
Depression: 6 people, 13.33%
Muscle Twitching: 5 people, 11.11%
Muscle Spasms (muscle contraction): 5 people, 11.11%

What are the existing conditions these people have? *

Parkinson's Disease: 6 people, 13.33%
Depression: 6 people, 13.33%
Neuralgia (pain in one or more nerves): 5 people, 11.11%
Pain In Extremity: 3 people, 6.67%
Sciatica (a set of symptoms including pain caused by general compression or irritation of one of five spinal nerve roots of each sciatic nerve): 3 people, 6.67%
Gastrointestinal Stromal Tumor: 2 people, 4.44%
Schizophrenia (a mental disorder characterized by a breakdown of thought processes): 2 people, 4.44%
Schizoid Personality Disorder (a personality disorder characterized by a lack of interest in social relationships): 2 people, 4.44%
Muscle Spasms (muscle contraction): 2 people, 4.44%
Psychotic Disorder: 2 people, 4.44%

* Approximation only. Some reports may have incomplete information.

Do you take Oxycontin and have Muscle rigidity?

- Check whether Muscle rigidity is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Oxycontin:

Oxycontin (212,533 reports)

Muscle rigidity treatments and more:

Muscle rigidity (16,888 reports)

Browse all side effects of Oxycontin:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Muscle rigidity:

Muscle rigidity (784 drugs)

Browse all the conditions that are associated with Muscle rigidity:

Muscle rigidity (1,035 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on oxycodone hydrochloride (the active ingredients of Oxycontin) and Oxycontin (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.