Ozempic and Injection site reaction - a phase IV clinical study of FDA data

Summary:

Injection site reaction is reported as a side effect among people who take Ozempic (semaglutide), especially for people who are female, 60+ old, have been taking the drug for 1 - 6 months also take Dupixent, and have Type 2 diabetes.

The phase IV clinical study analyzes which people have Injection site reaction when taking Ozempic. It is created by eHealthMe based on reports of 28,954 people who have side effects when taking Ozempic from the FDA, and is updated regularly.

What is Ozempic?

Ozempic has active ingredients of semaglutide. It is often used in weight loss. eHealthMe is studying from 29,761 Ozempic users. Check the latest studies of Ozempic.

What is Injection site reaction?

Injection site reaction is found to be associated with 1,128 drugs and 1,074 conditions by eHealthMe. Check the latest studies of Injection site reaction.

On Jul, 10, 2026

28,954 people reported to have side effects when taking Ozempic.
Among them, 49 people (0.17%) have Injection site reaction.

Could Ozempic cause Injection site reaction?

Among these 49 people:

How long have people been on Ozempic when they have Injection site reaction? *

What is the gender of people who have Injection site reaction when taking Ozempic? *

female: 79.59 %
male: 20.41 %

What is the age of people who have Injection site reaction when taking Ozempic? *

What are other drugs people take besides Ozempic? *

What are other side effects people have besides Injection site reaction? *

Injection Site Pain: 14 people, 28.57%
Nausea (feeling of having an urge to vomit): 7 people, 14.29%
Diarrhea: 6 people, 12.24%
Abdominal Pain Upper: 6 people, 12.24%
Injection Site Erythema (redness at injection site): 6 people, 12.24%
Dizziness: 5 people, 10.20%
Injection Site Swelling: 5 people, 10.20%
Constipation: 5 people, 10.20%
Injection Site Urticaria (rash of round, red welts on the skin at injection site): 4 people, 8.16%
Malaise (a feeling of general discomfort or uneasiness): 3 people, 6.12%

What are the existing conditions these people have? *

Type 2 Diabetes: 18 people, 36.73%
Diabetes: 3 people, 6.12%
Asthma: 3 people, 6.12%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 2 people, 4.08%
Insulin Resistance: 2 people, 4.08%
Weight Decreased: 1 person, 2.04%
Psoriatic Arthropathy (inflammation of the skin and joints with kin condition which typically causes patches (plaques) of red, scaly skin to develop): 1 person, 2.04%
Psoriasis (immune-mediated disease that affects the skin): 1 person, 2.04%
Primary Pulmonary Hypertension (primary high blood pressure that affects the arteries in the lungs and the right side of your heart): 1 person, 2.04%
Hypophosphatasia (metabolic bone disease): 1 person, 2.04%

* Approximation only. Some reports may have incomplete information.

Do you take Ozempic and have Injection site reaction?

- Check whether Injection site reaction is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
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Related studies:

Effectiveness of, long term effects of, and alternative drugs to Ozempic:

Ozempic (29,761 reports)

Browse all side effects of Ozempic:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Injection site reaction:

Injection site reaction (1,128 drugs)

Browse all the conditions that are associated with Injection site reaction:

Injection site reaction (1,074 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on semaglutide (the active ingredients of Ozempic) and Ozempic (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.