Paliperidone and Muscle rigidity - a phase IV clinical study of FDA data

Summary:

Muscle rigidity is reported as a side effect among people who take Paliperidone (paliperidone), especially for people who are female, 20-29 old, have been taking the drug for < 1 month also take Aripiprazole, and have Schizophrenia.

The phase IV clinical study analyzes which people have Muscle rigidity when taking Paliperidone. It is created by eHealthMe based on reports of 5,118 people who have side effects when taking Paliperidone from the FDA, and is updated regularly.

What is Paliperidone?

Paliperidone has active ingredients of paliperidone. eHealthMe is studying from 5,137 Paliperidone users. Check the latest studies of Paliperidone.

What is Muscle rigidity?

Muscle rigidity (muscle stiffness) is found to be associated with 780 drugs and 1,036 conditions by eHealthMe. Check the latest studies of Muscle rigidity.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 31, 2026

5,118 people reported to have side effects when taking Paliperidone.
Among them, 51 people (1.0%) have Muscle rigidity.

Could Paliperidone cause Muscle rigidity?

Among these 51 people:

How long have people been on Paliperidone when they have Muscle rigidity? *

What is the gender of people who have Muscle rigidity when taking Paliperidone? *

female: 54.55 %
male: 45.45 %

What is the age of people who have Muscle rigidity when taking Paliperidone? *

What are other drugs people take besides Paliperidone? *

What are other side effects people have besides Muscle rigidity? *

Tremor (trembling or shaking movements in one or more parts of your body): 24 people, 47.06%
Neuroleptic Malignant Syndrome (a life-threatening neurological disorder most often caused by an adverse reaction to neuroleptic or antipsychotic agents): 18 people, 35.29%
Agitation (state of anxiety or nervous excitement): 13 people, 25.49%
Fever: 12 people, 23.53%
Catatonia (unresponsive to external stimuli): 12 people, 23.53%
Blood Creatine Phosphokinase Increased: 12 people, 23.53%
Hyperhidrosis (abnormally increased sweating): 12 people, 23.53%
Leukocytosis (increased white blood cells): 9 people, 17.65%
Salivary Hypersecretion (excess saliva secretion): 9 people, 17.65%
Drowsiness: 8 people, 15.69%

What are the existing conditions these people have? *

Schizophrenia (a mental disorder characterized by a breakdown of thought processes): 13 people, 25.49%
Psychotic Disorder: 9 people, 17.65%
Major Depression (a mood state that goes well beyond temporarily feeling sad or blue. it is a serious medical illness that affects one's thoughts, feelings): 7 people, 13.73%
Schizoaffective Disorder (a mental disorder characterized by disordered thought): 5 people, 9.80%
Schizophrenia, Paranoid Type (delusions and auditory hallucinations but relatively normal intellectual functioning and expression of affect): 3 people, 5.88%
Bipolar Disorder (mood disorder): 3 people, 5.88%
Schizoaffective Disorder Bipolar Type (mental illness featuring schizophrenia and a mood disorder with mania): 2 people, 3.92%
Affective Disorder (mental disorder): 1 person, 1.96%
Homicidal Ideation (thoughts about human killing another human): 1 person, 1.96%
Insomnia (sleeplessness): 1 person, 1.96%

* Approximation only. Some reports may have incomplete information.

Do you take Paliperidone and have Muscle rigidity?

- Check whether Muscle rigidity is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Paliperidone:

Paliperidone (5,137 reports)

Muscle rigidity treatments and more:

Muscle rigidity (16,888 reports)

Browse all side effects of Paliperidone:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Muscle rigidity:

Muscle rigidity (780 drugs)

Browse all the conditions that are associated with Muscle rigidity:

Muscle rigidity (1,036 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on paliperidone (the active ingredients of Paliperidone) and Paliperidone (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.