Palladone and Fatigue aggravated - a phase IV clinical study of FDA data

Summary:

Fatigue aggravated is reported as a side effect among people who take Palladone (hydromorphone hydrochloride), especially for people who are male, 60+ old, have been taking the drug for < 1 month also take Dhc Plus, and have Pain.

The phase IV clinical study analyzes which people have Fatigue aggravated when taking Palladone. It is created by eHealthMe based on reports of 2,543 people who have side effects when taking Palladone from the FDA, and is updated regularly.

What is Palladone?

Palladone has active ingredients of hydromorphone hydrochloride. eHealthMe is studying from 2,546 Palladone users. Check the latest studies of Palladone.

What is Fatigue aggravated?

Fatigue aggravated (feeling of tiredness) is found to be associated with 3,164 drugs and 1,117 conditions by eHealthMe. Check the latest studies of Fatigue aggravated.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 31, 2026

2,543 people reported to have side effects when taking Palladone.
Among them, 66 people (2.6%) have Fatigue aggravated.

Could Palladone cause Fatigue aggravated?

Among these 66 people:

How long have people been on Palladone when they have Fatigue aggravated? *

What is the gender of people who have Fatigue aggravated when taking Palladone? *

female: 43.75 %
male: 56.25 %

What is the age of people who have Fatigue aggravated when taking Palladone? *

What are other drugs people take besides Palladone? *

Hysingla Er: 29 people, 43.94%
Dhc Plus: 29 people, 43.94%
Hydrocodone Bitartrate And Acetaminophen: 25 people, 37.88%
Oxycontin: 15 people, 22.73%
Ms Contin: 12 people, 18.18%
Dexamethasone: 10 people, 15.15%
Oxycodone: 9 people, 13.64%
Pantoprazole: 9 people, 13.64%
Tramadol: 9 people, 13.64%
Morphine Sulfate: 9 people, 13.64%

What are other side effects people have besides Fatigue aggravated? *

Drug Dependence: 28 people, 42.42%
Appetite - Decreased (decreased appetite occurs when you have a reduced desire to eat): 16 people, 24.24%
Pain: 16 people, 24.24%
Depression: 15 people, 22.73%
Overdose: 15 people, 22.73%
Headache (pain in head): 15 people, 22.73%
Nausea (feeling of having an urge to vomit): 14 people, 21.21%
Weight Decreased: 13 people, 19.70%
Drug Withdrawal Syndrome (interfere with normal social, occupational, or other functioning. are not due to another medical condition, drug use, or discontinuation): 11 people, 16.67%
Stress And Anxiety: 11 people, 16.67%

What are the existing conditions these people have? *

Pain: 21 people, 31.82%
Lung Cancer - Non-Small Cell (lung cancer): 8 people, 12.12%
Prostate Cancer: 5 people, 7.58%
Multiple Myeloma (cancer of the plasma cells): 4 people, 6.06%
Metastases To Bone (cancer spreads to bone): 3 people, 4.55%
Tumor Pain: 2 people, 3.03%
Attention Deficit Hyperactivity Disorder (a chronic condition including attention difficulty, hyperactivity, and impulsiveness): 2 people, 3.03%
Cancer Pain: 2 people, 3.03%
Colitis (inflammation of colon): 2 people, 3.03%
Foetal Exposure During Pregnancy (exposing your unborn child to contraindicated in pregnancy leads birth defect): 2 people, 3.03%

* Approximation only. Some reports may have incomplete information.

Do you take Palladone and have Fatigue aggravated?

- Check whether Fatigue aggravated is associated with a drug or a condition
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Related studies:

Effectiveness of, long term effects of, and alternative drugs to Palladone:

Palladone (2,546 reports)

Browse all side effects of Palladone:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Fatigue aggravated:

Fatigue aggravated (3,164 drugs)

Browse all the conditions that are associated with Fatigue aggravated:

Fatigue aggravated (1,117 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on hydromorphone hydrochloride (the active ingredients of Palladone) and Palladone (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.