Pamelor and Intervertebral disc degeneration - a phase IV clinical study of FDA data

Summary:

Intervertebral disc degeneration is reported as a side effect among people who take Pamelor (nortriptyline hydrochloride), especially for people who are female, 60+ old, also take Oxycontin, and have Sleep apnea syndrome.

The phase IV clinical study analyzes which people have Intervertebral disc degeneration when taking Pamelor. It is created by eHealthMe based on reports of 3,798 people who have side effects when taking Pamelor from the FDA, and is updated regularly.

What is Pamelor?

Pamelor has active ingredients of nortriptyline hydrochloride. It is often used in migraine. eHealthMe is studying from 4,069 Pamelor users. Check the latest studies of Pamelor.

What is Intervertebral disc degeneration?

Intervertebral disc degeneration (spinal disc degeneration) is found to be associated with 1,316 drugs and 1,496 conditions by eHealthMe. Check the latest studies of Intervertebral disc degeneration.

On Jul, 16, 2026

3,798 people reported to have side effects when taking Pamelor.
Among them, 36 people (0.95%) have Intervertebral disc degeneration.

Could Pamelor cause Intervertebral disc degeneration?

Among these 36 people:

What is the gender of people who have Intervertebral disc degeneration when taking Pamelor? *

female: 80.56 %
male: 19.44 %

What is the age of people who have Intervertebral disc degeneration when taking Pamelor? *

What are other drugs people take besides Pamelor? *

What are other side effects people have besides Intervertebral disc degeneration? *

Pain: 25 people, 69.44%
Stress And Anxiety: 25 people, 69.44%
Intervertebral Disc Protrusion (spinal disc protrusion): 22 people, 61.11%
Gait Disturbance: 22 people, 61.11%
Joint Pain: 21 people, 58.33%
Back Pain: 21 people, 58.33%
Neuropathy Peripheral (surface nerve damage): 21 people, 58.33%
Muscle Spasms (muscle contraction): 21 people, 58.33%
Hypoaesthesia (reduced sense of touch or sensation): 20 people, 55.56%
Osteonecrosis Of Jaw (death of bone of jaw): 20 people, 55.56%

What are the existing conditions these people have? *

Sleep Apnea Syndrome: 14 people, 38.89%
Pain: 7 people, 19.44%
Metastases To Bone (cancer spreads to bone): 6 people, 16.67%
Bone Density Decreased: 4 people, 11.11%
Bone Loss: 4 people, 11.11%
Muscle Spasms (muscle contraction): 3 people, 8.33%
High Blood Pressure: 3 people, 8.33%
Stroke (sudden death of a portion of the brain cells due to a lack of oxygen): 3 people, 8.33%
Type 2 Diabetes: 3 people, 8.33%
Bladder Cancer: 3 people, 8.33%

* Approximation only. Some reports may have incomplete information.

Do you take Pamelor and have Intervertebral disc degeneration?

- Check whether Intervertebral disc degeneration is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Pamelor:

Pamelor (4,069 reports)

Browse all side effects of Pamelor:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Intervertebral disc degeneration:

Intervertebral disc degeneration (1,316 drugs)

Browse all the conditions that are associated with Intervertebral disc degeneration:

Intervertebral disc degeneration (1,496 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on nortriptyline hydrochloride (the active ingredients of Pamelor) and Pamelor (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.