Paracetamol and Thyrotoxic crisis - a phase IV clinical study of FDA data

Summary:

Thyrotoxic crisis is reported as a side effect among people who take Paracetamol (acetaminophen), especially for people who are female, 40-49 old, also take Opdivo, and have Depression.

The phase IV clinical study analyzes which people have Thyrotoxic crisis when taking Paracetamol. It is created by eHealthMe based on reports of 114,713 people who have side effects when taking Paracetamol from the FDA, and is updated regularly.

What is Paracetamol?

Paracetamol has active ingredients of acetaminophen. It is often used in pain. eHealthMe is studying from 115,650 Paracetamol users. Check the latest studies of Paracetamol.

What is Thyrotoxic crisis?

Thyrotoxic crisis (a life threatening condition due to excess secretion of thyroid hormone) is found to be associated with 109 drugs and 190 conditions by eHealthMe. Check the latest studies of Thyrotoxic crisis.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 23, 2026

114,713 people reported to have side effects when taking Paracetamol.
Among them, 25 people (0.02%) have Thyrotoxic crisis.

Could Paracetamol cause Thyrotoxic crisis?

Among these 25 people:

What is the gender of people who have Thyrotoxic crisis when taking Paracetamol? *

female: 86.36 %
male: 13.64 %

What is the age of people who have Thyrotoxic crisis when taking Paracetamol? *

What are other drugs people take besides Paracetamol? *

What are other side effects people have besides Thyrotoxic crisis? *

Weight Loss: 5 people, 20.00%
Dry Mouth: 5 people, 20.00%
Swallowing Difficulty: 5 people, 20.00%
Oedema (fluid collection in tissue): 5 people, 20.00%
Pancreatitis (inflammation of pancreas): 5 people, 20.00%
Skin Hyperpigmentation (disorders affect the colour of your skin): 5 people, 20.00%
General Physical Health Deterioration (weak health status): 5 people, 20.00%
Scar: 5 people, 20.00%
Pneumonia: 4 people, 16.00%
Vitiligo (pigment is lost from areas of the skin): 4 people, 16.00%

What are the existing conditions these people have? *

Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 10 people, 40.00%
High Blood Pressure: 10 people, 40.00%
Depression: 10 people, 40.00%
Malignant Melanoma (skin cancer rises from melancytes): 6 people, 24.00%
Stable Angina (a constant chest pain): 5 people, 20.00%
Metastatic Malignant Melanoma (spreadable cancer tumour of melanine): 5 people, 20.00%
Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 3 people, 12.00%
Sinus Arrhythmia (a naturally occurring variation in heart rate that occurs during a breathing cycle): 2 people, 8.00%

* Approximation only. Some reports may have incomplete information.

Do you take Paracetamol and have Thyrotoxic crisis?

- Check whether Thyrotoxic crisis is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Paracetamol:

Paracetamol (115,650 reports)

Browse all side effects of Paracetamol:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Thyrotoxic crisis:

Thyrotoxic crisis (109 drugs)

Browse all the conditions that are associated with Thyrotoxic crisis:

Thyrotoxic crisis (190 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on acetaminophen (the active ingredients of Paracetamol) and Paracetamol (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.