Paroxetine and Hyporeflexia - a phase IV clinical study of FDA data

Summary:

Hyporeflexia is reported as a side effect among people who take Paroxetine (paroxetine hydrochloride), especially for people who are female, 60+ old, have been taking the drug for < 1 month also take Lansoprazole, and have Depression.

The phase IV clinical study analyzes which people have Hyporeflexia when taking Paroxetine. It is created by eHealthMe based on reports of 63,800 people who have side effects when taking Paroxetine from the FDA, and is updated regularly.

What is Paroxetine?

Paroxetine has active ingredients of paroxetine hydrochloride. It is often used in stress and anxiety. eHealthMe is studying from 65,088 Paroxetine users. Check the latest studies of Paroxetine.

What is Hyporeflexia?

Hyporeflexia (a condition of below normal or absent reflexes) is found to be associated with 452 drugs and 593 conditions by eHealthMe. Check the latest studies of Hyporeflexia.

On Jul, 07, 2026

63,800 people reported to have side effects when taking Paroxetine.
Among them, 45 people (0.07%) have Hyporeflexia.

Among these 45 people:

How long have people been on Paroxetine when they have Hyporeflexia? *

What is the gender of people who have Hyporeflexia when taking Paroxetine? *

female: 84.21 %
male: 15.79 %

What is the age of people who have Hyporeflexia when taking Paroxetine? *

What are other drugs people take besides Paroxetine? *

What are other side effects people have besides Hyporeflexia? *

Hypotonia (low muscle tone): 11 people, 24.44%
Foetal Exposure During Pregnancy (exposing your unborn child to contraindicated in pregnancy leads birth defect): 10 people, 22.22%
Hypoglycemia (low blood sugar): 9 people, 20.00%
Weakness: 8 people, 17.78%
Blood Creatine Phosphokinase Increased: 8 people, 17.78%
Speech Impairment (Adult) (inability to speak (adult)): 8 people, 17.78%
Muscle Aches (muscle pain): 7 people, 15.56%
Muscle Spasms (muscle contraction): 7 people, 15.56%
Fatigue (feeling of tiredness): 7 people, 15.56%
Anaemia (lack of blood): 6 people, 13.33%

What are the existing conditions these people have? *

Depression: 4 people, 8.89%
Arrhythmias (irregular heartbeat): 3 people, 6.67%
Bipolar Disorder (mood disorder): 2 people, 4.44%
Urinary Tract Infection: 1 person, 2.22%
Seizures (abnormal excessive or synchronous neuronal activity in the brain): 1 person, 2.22%
Oesophagitis (inflammation of oesophagus): 1 person, 2.22%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 1 person, 2.22%
Iron Deficiency: 1 person, 2.22%
Intentional Self-Injury: 1 person, 2.22%
Hyperlipidaemia (presence of excess lipids in the blood): 1 person, 2.22%

* Approximation only. Some reports may have incomplete information.

Do you take Paroxetine and have Hyporeflexia?

- Check whether Hyporeflexia is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Paroxetine:

Paroxetine (65,088 reports)

Hyporeflexia treatments and more:

Hyporeflexia (3,443 reports)

Browse all side effects of Paroxetine:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Hyporeflexia:

Hyporeflexia (452 drugs)

Browse all the conditions that are associated with Hyporeflexia:

Hyporeflexia (593 conditions)

Related publications that referenced our studies

Coskun M, Adak I, Akaltun I, "Bilateral gynecomastia in a preadolescent boy while under treatment with methylphenidate and paroxetine", Journal of clinical psychopharmacology, 2014 Aug .
Coskun M, Adak I, Akaltun I, "Bilateral gynecomastia in a preadolescent boy while under treatment with methylphenidate and paroxetine", Journal of clinical psychopharmacology, 2014 Aug .

How the study uses the data?

The study uses data from the FDA. It is based on paroxetine hydrochloride (the active ingredients of Paroxetine) and Paroxetine (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.