Paxlovid and Psychomotor hyperactivity - a phase IV clinical study of FDA data

Summary:

Psychomotor hyperactivity is reported as a side effect among people who take Paxlovid (nirmatrelvir; ritonavir), especially for people who are female, 60+ old, have been taking the drug for < 1 month also take Clonazepam, and have Diabetes.

The phase IV clinical study analyzes which people have Psychomotor hyperactivity when taking Paxlovid. It is created by eHealthMe based on reports of 38,421 people who have side effects when taking Paxlovid from the FDA, and is updated regularly.

What is Paxlovid?

Paxlovid has active ingredients of nirmatrelvir; ritonavir. eHealthMe is studying from 38,422 Paxlovid users. Check the latest studies of Paxlovid.

What is Psychomotor hyperactivity?

Psychomotor hyperactivity (feelings of extreme restlessness) is found to be associated with 886 drugs and 1,101 conditions by eHealthMe. Check the latest studies of Psychomotor hyperactivity.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 03, 2026

38,421 people reported to have side effects when taking Paxlovid.
Among them, 16 people (0.04%) have Psychomotor hyperactivity.

Could Paxlovid cause Psychomotor hyperactivity?

Among these 16 people:

How long have people been on Paxlovid when they have Psychomotor hyperactivity? *

What is the gender of people who have Psychomotor hyperactivity when taking Paxlovid? *

female: 80 %
male: 20 %

What is the age of people who have Psychomotor hyperactivity when taking Paxlovid? *

What are other drugs people take besides Paxlovid? *

What are other side effects people have besides Psychomotor hyperactivity? *

Insomnia (sleeplessness): 8 people, 50.00%
Taste - Impaired: 3 people, 18.75%
Agitation (state of anxiety or nervous excitement): 3 people, 18.75%
Hallucinations (sensations that appear real but are created by your mind): 2 people, 12.50%
Diarrhea: 2 people, 12.50%
Energy Increased: 2 people, 12.50%
Confusional State: 2 people, 12.50%
Dizziness: 2 people, 12.50%
Feeling Abnormal: 2 people, 12.50%
Tremor (trembling or shaking movements in one or more parts of your body): 2 people, 12.50%

What are the existing conditions these people have? *

Diabetes: 2 people, 12.50%
Wheezing (a high-pitched whistling sound made while you breath): 1 person, 6.25%
Migraine (headache): 1 person, 6.25%
Mantle Cell Lymphoma (cancer of lymphocytes, a type of white blood cell): 1 person, 6.25%
High Blood Pressure: 1 person, 6.25%
High Blood Cholesterol: 1 person, 6.25%
Enlarged Prostate: 1 person, 6.25%
Cough: 1 person, 6.25%
Bone Marrow Conditioning Regimen: 1 person, 6.25%

* Approximation only. Some reports may have incomplete information.

Do you take Paxlovid and have Psychomotor hyperactivity?

- Check whether Psychomotor hyperactivity is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Paxlovid:

Paxlovid (38,422 reports)

Browse all side effects of Paxlovid:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Psychomotor hyperactivity:

Psychomotor hyperactivity (886 drugs)

Browse all the conditions that are associated with Psychomotor hyperactivity:

Psychomotor hyperactivity (1,101 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on nirmatrelvir; ritonavir (the active ingredients of Paxlovid) and Paxlovid (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.