Pemetrexed and Angina pectoris aggravated - a phase IV clinical study of FDA data

Summary:

Angina pectoris aggravated is reported as a side effect among people who take Pemetrexed (pemetrexed), especially for people who are female, 50-59 old, have been taking the drug for < 1 month also take Nintedanib, and have Lung adenocarcinoma.

The phase IV clinical study analyzes which people have Angina pectoris aggravated when taking Pemetrexed. It is created by eHealthMe based on reports of 17,478 people who have side effects when taking Pemetrexed from the FDA, and is updated regularly.

What is Pemetrexed?

Pemetrexed has active ingredients of pemetrexed. eHealthMe is studying from 17,491 Pemetrexed users. Check the latest studies of Pemetrexed.

What is Angina pectoris aggravated?

Angina pectoris aggravated (chest pain due to ischemia of the heart muscle) is found to be associated with 1,383 drugs and 654 conditions by eHealthMe. Check the latest studies of Angina pectoris aggravated.

On Aug, 03, 2026

17,478 people reported to have side effects when taking Pemetrexed.
Among them, 19 people (0.11%) have Angina pectoris aggravated.

Could Pemetrexed cause Angina pectoris aggravated?

Among these 19 people:

How long have people been on Pemetrexed when they have Angina pectoris aggravated? *

What is the gender of people who have Angina pectoris aggravated when taking Pemetrexed? *

female: 86.67 %
male: 13.33 %

What is the age of people who have Angina pectoris aggravated when taking Pemetrexed? *

What are other drugs people take besides Pemetrexed? *

What are other side effects people have besides Angina pectoris aggravated? *

Febrile Neutropenia (fever with reduced white blood cells): 10 people, 52.63%
Oedema Peripheral (superficial swelling): 10 people, 52.63%
Oesophagitis (inflammation of oesophagus): 10 people, 52.63%
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 9 people, 47.37%
Ocular Discomfort (a generic expression when there is lack of ease in/about the eyes): 9 people, 47.37%
Mucosal Inflammation (infection of mucous membrane): 9 people, 47.37%
Liver Disorder (liver diseases): 9 people, 47.37%
Hepatotoxicity (chemical-driven liver damage): 5 people, 26.32%
Anaemia (lack of blood): 3 people, 15.79%
Arrhythmias (irregular heartbeat): 2 people, 10.53%

What are the existing conditions these people have? *

Lung Adenocarcinoma (a form of non-small cell lung cancer): 9 people, 47.37%
Lung Cancer - Non-Small Cell (lung cancer): 6 people, 31.58%
Non-Small Cell Lung Cancer Stage Iv: 2 people, 10.53%
Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect): 1 person, 5.26%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 1 person, 5.26%
Adenocarcinoma (malignant tumour formed from glandular structures in epithelial tissue): 1 person, 5.26%
Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 1 person, 5.26%
Chronic Obstructive Pulmonary Disease (a progressive disease that makes it hard to breathe): 1 person, 5.26%
Constipation: 1 person, 5.26%
Depression: 1 person, 5.26%

* Approximation only. Some reports may have incomplete information.

Do you take Pemetrexed and have Angina pectoris aggravated?

- Check whether Angina pectoris aggravated is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
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Related studies:

Effectiveness of, long term effects of, and alternative drugs to Pemetrexed:

Pemetrexed (17,491 reports)

Browse all side effects of Pemetrexed:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Angina pectoris aggravated:

Angina pectoris aggravated (1,383 drugs)

Browse all the conditions that are associated with Angina pectoris aggravated:

Angina pectoris aggravated (654 conditions)

Related publications that referenced our studies

Gota V, Kavathiya K, Doshi K, Gurjar M, Damodaran SE, Noronha V, Joshi A, Prabhash K, "High plasma exposure to pemetrexed leads to severe hyponatremia in patients with advanced non small cell lung cancer receiving pemetrexed-platinum doublet chemotherapy", Cancer management and research, 2017 Jan .
Gota V, Kavathiya K, Doshi K, Gurjar M, Damodaran SE, Noronha V, Joshi A, Prabhash K, "High plasma exposure to pemetrexed leads to severe hyponatremia in patients with advanced non small cell lung cancer receiving pemetrexed-platinum doublet chemotherapy", Cancer management and research, 2017 Jan .

How the study uses the data?

The study uses data from the FDA. It is based on pemetrexed (the active ingredients of Pemetrexed) and Pemetrexed (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

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