Pemetrexed and Hypopituitarism - a phase IV clinical study of FDA data

Summary:

Hypopituitarism is reported as a side effect among people who take Pemetrexed (pemetrexed), especially for people who are male, 60+ old, have been taking the drug for < 1 month also take Yervoy, and have Non-small cell lung cancer recurrent.

The phase IV clinical study analyzes which people have Hypopituitarism when taking Pemetrexed. It is created by eHealthMe based on reports of 17,478 people who have side effects when taking Pemetrexed from the FDA, and is updated regularly.

What is Pemetrexed?

Pemetrexed has active ingredients of pemetrexed. eHealthMe is studying from 17,491 Pemetrexed users. Check the latest studies of Pemetrexed.

What is Hypopituitarism?

Hypopituitarism (diminished hormone secretion by the pituitary gland, causing dwarfism in children and premature aging in adults) is found to be associated with 202 drugs and 451 conditions by eHealthMe. Check the latest studies of Hypopituitarism.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 03, 2026

17,478 people reported to have side effects when taking Pemetrexed.
Among them, 51 people (0.29%) have Hypopituitarism.

Among these 51 people:

How long have people been on Pemetrexed when they have Hypopituitarism? *

What is the gender of people who have Hypopituitarism when taking Pemetrexed? *

female: 11.76 %
male: 88.24 %

What is the age of people who have Hypopituitarism when taking Pemetrexed? *

What are other drugs people take besides Pemetrexed? *

What are other side effects people have besides Hypopituitarism? *

Adrenal Insufficiency (a condition in which the adrenal glands do not produce adequate amounts of steroids): 14 people, 27.45%
Thrombocytopenia (decrease of platelets in blood): 12 people, 23.53%
Malaise (a feeling of general discomfort or uneasiness): 12 people, 23.53%
Appetite - Decreased (decreased appetite occurs when you have a reduced desire to eat): 10 people, 19.61%
Joint Pain: 7 people, 13.73%
Nausea (feeling of having an urge to vomit): 7 people, 13.73%
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 7 people, 13.73%
Febrile Neutropenia (fever with reduced white blood cells): 7 people, 13.73%
Constipation: 7 people, 13.73%
Pneumonia: 7 people, 13.73%

What are the existing conditions these people have? *

Non-Small Cell Lung Cancer Recurrent (type of epithelial lung cancer reoccurrence): 37 people, 72.55%
Lung Cancer - Non-Small Cell (lung cancer): 16 people, 31.37%
Hepatitis B: 3 people, 5.88%
Type 2 Diabetes: 2 people, 3.92%
Cachexia (loss of weight): 2 people, 3.92%
Lung Adenocarcinoma (a form of non-small cell lung cancer): 2 people, 3.92%
High Blood Pressure: 1 person, 1.96%
Diabetes Insipidus (diabetes caused by a deficiency of the pituitary hormone vasopressin, which regulates kidney function): 1 person, 1.96%
Dyslipidaemia (abnormal amount of lipids): 1 person, 1.96%
High Blood Cholesterol: 1 person, 1.96%

* Approximation only. Some reports may have incomplete information.

Do you take Pemetrexed and have Hypopituitarism?

- Check whether Hypopituitarism is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Pemetrexed:

Pemetrexed (17,491 reports)

Hypopituitarism treatments and more:

Hypopituitarism (11,449 reports)

Browse all side effects of Pemetrexed:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Hypopituitarism:

Hypopituitarism (202 drugs)

Browse all the conditions that are associated with Hypopituitarism:

Hypopituitarism (451 conditions)

Related publications that referenced our studies

Gota V, Kavathiya K, Doshi K, Gurjar M, Damodaran SE, Noronha V, Joshi A, Prabhash K, "High plasma exposure to pemetrexed leads to severe hyponatremia in patients with advanced non small cell lung cancer receiving pemetrexed-platinum doublet chemotherapy", Cancer management and research, 2017 Jan .
Gota V, Kavathiya K, Doshi K, Gurjar M, Damodaran SE, Noronha V, Joshi A, Prabhash K, "High plasma exposure to pemetrexed leads to severe hyponatremia in patients with advanced non small cell lung cancer receiving pemetrexed-platinum doublet chemotherapy", Cancer management and research, 2017 Jan .

How the study uses the data?

The study uses data from the FDA. It is based on pemetrexed (the active ingredients of Pemetrexed) and Pemetrexed (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.