Penicillin and Acute hepatic failure - a phase IV clinical study of FDA data

Summary:

Acute hepatic failure is reported as a side effect among people who take Penicillin (penicillin g potassium), especially for people who are female, 60+ old, also take Hydrocortisone, and have Headache.

The phase IV clinical study analyzes which people have Acute hepatic failure when taking Penicillin. It is created by eHealthMe based on reports of 7,964 people who have side effects when taking Penicillin from the FDA, and is updated regularly.

What is Penicillin?

Penicillin has active ingredients of penicillin g potassium. It is often used in strep throat. eHealthMe is studying from 8,567 Penicillin users. Check the latest studies of Penicillin.

What is Acute hepatic failure?

Acute hepatic failure is found to be associated with 709 drugs and 1,185 conditions by eHealthMe. Check the latest studies of Acute hepatic failure.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 27, 2026

7,964 people reported to have side effects when taking Penicillin.
Among them, 15 people (0.19%) have Acute hepatic failure.

Could Penicillin cause Acute hepatic failure?

Among these 15 people:

What is the gender of people who have Acute hepatic failure when taking Penicillin? *

female: 57.14 %
male: 42.86 %

What is the age of people who have Acute hepatic failure when taking Penicillin? *

What are other drugs people take besides Penicillin? *

Vancomycin Hydrochloride: 2 people, 13.33%
Ibuprofen: 2 people, 13.33%
Amoxicillin: 2 people, 13.33%
Ceftriaxone: 2 people, 13.33%
Clarithromycin: 2 people, 13.33%
Metronidazole: 2 people, 13.33%
Hydrocortisone: 2 people, 13.33%
Alcohol: 1 person, 6.67%
Caffeine: 1 person, 6.67%
Chantix: 1 person, 6.67%

What are other side effects people have besides Acute hepatic failure? *

Acute Kidney Failure: 7 people, 46.67%
Haemodynamic Instability (disturbances in the blood movement in our body): 5 people, 33.33%
Blood Creatinine Increased: 5 people, 33.33%
Blood Bilirubin Increased: 5 people, 33.33%
Alanine Aminotransferase Increased: 5 people, 33.33%
Respiratory Acidosis (respiratory failure or ventilatory failure, causes the ph of blood and other bodily fluids to decrease): 5 people, 33.33%
Arrhythmias (irregular heartbeat): 4 people, 26.67%
Haemoglobin Decreased: 4 people, 26.67%
Heart Rate Increased: 4 people, 26.67%
Blood Lactate Dehydrogenase Increased: 4 people, 26.67%

What are the existing conditions these people have? *

Bacterial Infection: 5 people, 33.33%
Brain Abscess: 5 people, 33.33%
Confusional State: 5 people, 33.33%
Headache (pain in head): 5 people, 33.33%
Streptococcal Infection: 4 people, 26.67%
Rashes (redness): 4 people, 26.67%
Weight Decreased: 1 person, 6.67%
Indigestion: 1 person, 6.67%
Depression: 1 person, 6.67%
Dyspnea (difficult or laboured breathing): 1 person, 6.67%

* Approximation only. Some reports may have incomplete information.

Do you take Penicillin and have Acute hepatic failure?

- Check whether Acute hepatic failure is associated with a drug or a condition
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- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Penicillin:

Penicillin (8,567 reports)

Browse all side effects of Penicillin:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Acute hepatic failure:

Acute hepatic failure (709 drugs)

Browse all the conditions that are associated with Acute hepatic failure:

Acute hepatic failure (1,185 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on penicillin g potassium (the active ingredients of Penicillin) and Penicillin (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.